ACCN1
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Official Full Name
amiloride-sensitive cation channel 1, neuronal -
Overview
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. -
Synonyms
ACCN1;amiloride-sensitive cation channel 1, neuronal;ACCN;ASIC2;ASIC2a;BNaC1;BNC1;degenerin;hBNaC1;MDEG;ACCN1_HUMAN;Acid sensing ion channel 2;Acid-sensing ion channel 2;Amiloride sensitive brain sodium channel;Amiloride sensitive cation channel 1 neuronal (degenerin);Amiloride sensitive cation channel 1 neuronal;Amiloride-sensitive brain sodium channel;Amiloride-sensitive cation channel neuronal 1;Brain sodium channel 1;Mammalian degenerin homolog;Neuronal amiloride sensitive cation channel 1;neuronal amiloride-sensitive cation channel 1
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Involved Pathway
ACCN1 involved in several pathways and played different roles in them. We selected most pathways ACCN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
ACCN1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ACCN1 itself. We selected most functions ACCN1 had, and list some proteins which have the same functions with ACCN1. You can find most of the proteins on our site.
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Interacting Protein
ACCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACCN1.
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References
- Benarroch, EE; et al. Acid-sensing cation channels Structure, function, and pathophysiologic implications. NEUROLOGY 82:628-635(2014).
- Sun, X; Zhao, D; et al. Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. ONCOLOGY REPORTS 30:2852-2858(2013).
