ABCG1
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 1 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. -
Synonyms
ABCG1;ATP-binding cassette, sub-family G (WHITE), member 1;ATP-binding cassette sub-family G member 1;ABC8;ATP binding cassette transporter 8;ABC transporter 8;homolog of Drosophila white;ATP-binding cassette transporter 8;ATP-binding cassette transporter member 1 of subfamily G;white protein homolog (ATP-binding cassette transporter 8);WHITE1;MGC34313
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Arabidopsis thaliana
- Mus musculus
- Dictyostelium Discoideum
- Wheat Germ
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- In Vitro Cell Free System
- GST
- His
- DDK
- Myc
Involved Pathway
ABCG1 involved in several pathways and played different roles in them. We selected most pathways ABCG1 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB11,Abca2,ABCC4,Abcb1b,ABCB10,ABCA13,ABCA5,ABCA1B,ABCG2A,ABCB1LB |
Protein Function
ABCG1 has several biochemical functions, for example, ADP binding,ATP binding,cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG1 itself. We selected most functions ABCG1 had, and list some proteins which have the same functions with ABCG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | P2RY1,ATP5B,DNAJA3,P2RX5,NME2B.1,PEO1,ICK,RTCB,TSSK3,DDR2 |
| protein heterodimerization activity | HIST1H4I,ADIPOR2,SYT16,JDP2,IKBKB,HIST1H3G,CEBPB,H2AFVA,MYF5,H2AFY2 |
| cholesterol binding | SYP,NPC1,OSBPL10,ERLIN2,OSBPL5,CETP,PTCH1,APOA2,OSBPL2,NPC2 |
| phospholipid transporter activity | ABCA13,OSBPL8,APOA1,ABCA1,ABCA4,MTTP,ABCA1B,ABCA4A,MFSD2AA,GLTPD1 |
| toxin transporter activity | SLC22A3,SLC17A3,SLC7A8,LRP6,SLC22A2 |
| protein dimerization activity | FIGLA,EBF3A,TCF3B,HEY1,AIFM1,TFE3B,MAX,MXD4,PEX3,LDB1A |
| phospholipid binding | APOH,PAFAH2,SYT14,PREX1,NSMAF,ANXA5,OTC,SPTBN2,MYOF,AGAP1 |
| protein homodimerization activity | CTBP2A,TPR,SLC22A1,CADM1B,PLEK,SH3GLB1,NADK2,CPNE1,NETO2,CRYBB2 |
| protein binding | WTIP,BRD9,S100A2,CHMP5,GNAT1,EIF4ENIF1,ACMSD,BRCC3,C6orf108,PLEK |
Interacting Protein
ABCG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG1.
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References
- Tsou, CY; Chen, CY; et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. ACTA PHYSIOLOGICA 210:799-810(2014).
- Baldan, A; Gonen, A; et al. ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis. JOURNAL OF IMMUNOLOGY 193:5637-5648(2014).
