ABCD2
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Official Full Name
ATP-binding cassette, sub-family D (ALD), member 2 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. -
Synonyms
ABCD2;ATP-binding cassette, sub-family D (ALD), member 2;ALDL1;ATP-binding cassette sub-family D member 2;ALDR;ALDRP;adrenoleukodystrophy-like 1;adrenoleukodystrophy-related protein;ABC39;hALDR
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Mus musculus
- Dictyostelium Discoideum
- E.coli
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- E.coli expression system
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
ABCD2 involved in several pathways and played different roles in them. We selected most pathways ABCD2 participated on our site, such as ABC transporters,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCG2A,ABCC10,ABCB6A,ABCB7,ABCG5,CFTR,ABCA1B,ABCC8,ABCA4,Abca2 |
| Peroxisome | PEX5,CROT,NUDT19,MPV17,SOD2,HAO2,DHRS4,AMACR,NOS2A,ABCD1 |
Protein Function
ABCD2 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCD2 itself. We selected most functions ABCD2 had, and list some proteins which have the same functions with ABCD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | SHMT1,MTERFD3,UGT1A2,DMRT1,NR6A1,PVRL2L,ADIPOQ,PLDN,Pdgfa&Pdgfb,SDCBP2 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC9,ABCB1,ABCD3,ABCD3B,ABCG2,Abcb1b,ABCG5,ABCG2A,ABCG8,ABCC11 |
| ATP binding | SRPK2,PMVK,PDK2,ABCD3A,HELZ,P2RX3A,ACTC1A,NTPCR,MCM7,TNIK |
| protein binding | RPS6KA1,ITGB1BP1,ASCC1,VANGL1,LRRC3,LTC4S,GRIFIN,CYHR1,MMS22L,PAAF1 |
Interacting Protein
ABCD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCD2.
PEX19;ABCD1
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References
- Liu, XX; Liu, JJ; et al. ABCD2 identifies a subclass of peroxisomes in mouse adipose tissue. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456:129-134(2015).
- Park, CY; Kim, HS; et al. ABCD2 Is a Direct Target of beta-Catenin and TCF-4: Implications for X- Linked Adrenoleukodystrophy Therapy. PLOS ONE 8:-(2013).
