ABCD1
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Official Full Name
5α-Androstane-3β,17β-diol -
Overview
5α-Androstane-3α, 17β-diol glucuronide is a C19 steroid and is either abbreviated as 3α Diol G, 5α Diol G or simply, α Diol G. It is produced mainly as a metabolite of testosterone and dihydrotestosterone (DHT). It is largely produced in target peripheral tissues such as the skin, especially around hair follicles. The stimulation by large amounts of 3α Diol G leads to excessive hair formation, notably where hair is not normally present in women. In recent years the interest in the measurement of this steroid has increased among clinical investigators studying women suffering from idiopathic hirsutism. Among the steroids known to be precursors for 3α Diol G are dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), dihydrotestosterone (DHT), androstenedione and testosterone. Only 3α Diol G has been shown to increase with hirsutism and decrease with treatment. This correlation has also been demonstrated in patients with polycystic ovarian syndrome (PCO). 3α Diol G determinations have therefore proved to be a useful indicator in a variety of ways including monitoring the progress of treatment of idiopathic hirsutism and women with PCO. Furthermore, diabetic patients (both men and women) under cyclosporine A therapy have shown increased 3α Diol G levels, a side effect resulting in the appearance of hair in previously hairless areas. -
Synonyms
5α-Androstane-3β,17β-diol
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Dictyostelium Discoideum
- Mus musculus
- E. coli
- Wheat Germ
- E.Coli or Yeast
- E.coli
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- Mammalian cells
- HEK293T
- E.coli expression system
- N-His
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
ABCD1 involved in several pathways and played different roles in them. We selected most pathways ABCD1 participated on our site, such as ABC transporters,Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | DAO.3,ACSL4B,SOD1,CRATA,HMGCLL1,CRATB,MPV17L,NOS2B,FAR2,PECI |
| ABC transporters | ABCA6,ABCA1,Abcb1b,ABCG3,ABCC12,ABCB4,ABCA3,ABCA9,ABCA5,ABCB10 |
Protein Function
ABCD1 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCD1 itself. We selected most functions ABCD1 had, and list some proteins which have the same functions with ABCD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GTF2F2A,MAP2K2A,TTLL10,IP6K2,ACACA,PKDCC,NPR1A,IPMK,OASL1,RIPK3 |
| protein homodimerization activity | APOA4,IKBKG,SMAD2,STK10,KIF20B,CASQ2,HEYL,ARID3A,ANXA9,CEBPA |
| ATPase activity, coupled to transmembrane movement of substances | ABCC11,ABCA8,ABCD4,ABCG8,Abcb1b,ABCA1B,IPO8,ABCB3L1,ABCB6,SFRP5 |
| enzyme binding | RAD9,HDAC2,IL6R,CPSF1,PEX5,HIST1H2AL,CSF3,BACE1,NPC2,TMBIM6 |
| ATPase activity | ABCE1,KIF23,ABCB1A,VPS4B,ASNA1,DDX3X,KIF27,WRNIP1,HSPD1,MLH1 |
| identical protein binding | DES,PAICS,AXIN1,PIP4K2C,DAPK3,ALDH4A1,RALYL,CLDND,COL18A1,HCFC1 |
| protein binding | SPON2,HSCB,HSPB9,HFE2,CYC1,STAT6,RGS6,WDR83,RAB3C,GLRB |
| transporter activity | TMEM184BA,SLC2A13B,LCN15,CPNE6,SLC37A4B,SLC6A20B,AP1B1,SLC4A1B,SLC23A1,Slc4a2 |
Interacting Protein
ABCD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCD1.
ABCD3;PEX19;Abcd1;Abcd3;RPSA;Abcd2;ABCD2;15-deoxy-delta(12,14;Rab5c;RAB7A;VPS26B;VAPA
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