ABCC6

  • Official Full Name

    ATP-binding cassette, sub-family C (CFTR/MRP), member 6

  • Overview

    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

  • Synonyms

    ABCC6;ATP-binding cassette, sub-family C (CFTR/MRP), member 6;ARA, pseudoxanthoma elasticum , PXE;URG7 protein;multidrug resistance-associated protein 6;EST349056;MLP1;MRP6;URG7;MOAT-E;ATP-binding cassette sub-family C member 6;multi-specific organic anion transporter E;anthracycline resistance-associated protein;ARA;PXE;PXE1;ABC34;GACI2;MOATE

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Chicken
  • Wheat Germ
  • Mammalian Cell
  • E.coli
  • HEK293
  • GST
  • His
  • His&T7
  • Non
  • His&Fc&Avi

    Involved Pathway

    ABCC6 involved in several pathways and played different roles in them. We selected most pathways ABCC6 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCG3,Abcb1b,ABCB6A,ABCD4,ABCA5,ABCG2A,ABCA8,ABCB1LB,ABCC5,ABCD3A

    Protein Function

    ABCC6 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC6 itself. We selected most functions ABCC6 had, and list some proteins which have the same functions with ABCC6. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity, coupled to transmembrane movement of substances ABCB7,ABCB8,ABCG2A,ABCB1,ABCB3L1,ABCA4A,ATP6V1D,ABCD3A,SFRP5,ABCA3
    ATP binding TLK2,MAP3K2,MKNK2B,MCM3,VRK1,ABCD3B,CLK2A,GSK3AA,NLRC3,WEE2
    transporter activity PDZK1,TMEM184BA,NUP155,SLCO4C1,SLC2A11B,SLC13A2,AP1G1,LCN2,TMEM184C,ABCF2

    Interacting Protein

    ABCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC6.

    A1BG;FURIN;NR4A1;AK2;CRYL1

    Resources

    References

    • Kirsch, AH; Smaczny, N; et al. Regulatory T Cells Improve Nephrocalcinosis but Not Dystrophic Cardiac Calcinosis in DBA/2 Mice. AMERICAN JOURNAL OF PATHOLOGY 183:382-390(2013).
    • Pomozi, V; Le Saux, O; et al. ABCC6 Is a Basolateral Plasma Membrane Protein. CIRCULATION RESEARCH 112:E148-+(2013).

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