ABCC11
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -
Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. -
Synonyms
ABCC11;ATP-binding cassette, sub-family C (CFTR/MRP), member 11;ATP-binding cassette sub-family C member 11;MRP8;ABCC 11;ATP binding cassette protein C11;ATP binding cassette sub family C (CFTR/MRP) member 11;ATP binding cassette sub family C member 11;ATP binding cassette transporter MRP8;ATP binding cassette transporter sub family C member 11;EWWD;Multi resistance protein 8;Multidrug resistance associated protein 8;OTTHUMP00000164191;WW;OTTHUMP00000164192;multi-resistance protein 8;ATP-binding cassette protein C11;ATP-binding cassette transporter MRP8;multidrug resistance-associated protein 8;ATP-binding cassette transporter
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABCC11-044H | Recombinant Human ABCC11 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABCC11-045H | Recombinant Human ABCC11 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABCC11-8123H | Recombinant Human ABCC11 protein, His & T7-tagged | E.coli | Human | His&T7 | Ile1141~Arg1382 |
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| ABCC11-5HCL | Recombinant Human ABCC11 cell lysate | Human | Non |
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| ABCC11-768HF | Recombinant Full Length Human ABCC11 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 553 amino acids |
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Involved Pathway
ABCC11 involved in several pathways and played different roles in them. We selected most pathways ABCC11 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB8,TAP2,ABCB7,ABCG3,ABCB4,Abcb1b,ABCD3,ABCA6,ABCC12,ABCC6 |
Protein Function
ABCC11 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC11 itself. We selected most functions ABCC11 had, and list some proteins which have the same functions with ABCC11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PNCK,OAS3,PIP4K2C,GLUL,NLRP3,SLKA,HIPK3A,SIK2A,PKMYT1,LIMK1A |
| ATPase activity, coupled to transmembrane movement of substances | ABCC9,ABCC5,IPO8,ABCD3A,ATP6V1D,ABCC2,ABCA1,ABCA7,ABCC12,ABCC10 |
| organic anion transmembrane transporter activity | SLCO1A2,SLC22A17,MFSD10,ABCC5,SLCO1B2,SLCO1A5,SLC22A31,ABCC2,SLC17A3,SLC22A20 |
Interacting Protein
ABCC11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC11.
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