ABCA8
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 8 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined. -
Synonyms
ABCA8;ATP-binding cassette, sub-family A (ABC1), member 8;ATP-binding cassette sub-family A member 8;KIAA0822;MGC163152
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABCA8-036H | Recombinant Human ABCA8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABCA8-3730H | Recombinant Human ABCA8, His-tagged | E.Coli or Yeast | Human | His | 1581 |
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| ABCA8-8141H | Recombinant Human ABCA8 protein, His & T7-tagged | E.coli | Human | His&T7 | Lys1263~Leu1456 |
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| Abca8-8143R | Recombinant Rat Abca8 protein, His & T7-tagged | E.coli | Rat | His&T7 | Ala1305~Glu1516 |
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| ABCA8-754HF | Recombinant Full Length Human ABCA8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 266 amino acids |
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Involved Pathway
ABCA8 involved in several pathways and played different roles in them. We selected most pathways ABCA8 participated on our site, such as ABC transporters,ABC-family proteins mediated transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCA3,ABCB6,ABCG1,SUR2A,ABCB4,ABCB3L1,ABCC1,ABCG2,ABCA13,ABCB5 |
| ABC-family proteins mediated transport | ABCD3B,ABCC9,ABCB8,ABCG4B,ABCC2,EIF2S3,ABCF1,EIF2S1,KCNJ11,APOA1B |
| Transmembrane transport of small molecules | FXYD6-FXYD2,SLC13A1,TRPC4B,DMTN,SLC1A7A,ANKH,ANO7,SLC35B2,ABCA4A,TTYH3B |
Protein Function
ABCA8 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA8 itself. We selected most functions ABCA8 had, and list some proteins which have the same functions with ABCA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSPA1B,NLRP7,DHX29,MAST4,MTHFD1,INSRB,EPHB3A,SGK2,ABCG2C,AXL |
| ATPase activity, coupled to transmembrane movement of substances | ABCA7,ABCA4,ABCB5,ABCA3,Abca2,ABCB10,ABCB8,IPO8,ABCD1,ABCG2 |
Interacting Protein
ABCA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA8.
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References
- Grinberg, M; Stober, RM; et al. Toxicogenomics directory of chemically exposed human hepatocytes. ARCHIVES OF TOXICOLOGY 88:2261-2287(2014).
- Hedditch, EL; Gao, B; et al. ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 106:-(2014).
