ABCA5
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 5 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. -
Synonyms
ABCA5;ATP-binding cassette, sub-family A (ABC1), member 5;ATP-binding cassette sub-family A member 5;EST90625;ATP-binding cassette A5;ABC13;FLJ16381;DKFZp451F117;DKFZp779N2435
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABCA5-394R | Recombinant Rat ABCA5 Protein | Mammalian Cell | Rat | His |
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| ABCA5-5744Z | Recombinant Zebrafish ABCA5 | Mammalian Cell | Zebrafish | His |
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| Abca5-8139M | Recombinant Mouse Abca5 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Val1401~Phe1642 |
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| ABCA5-49R | Recombinant Rat ABCA5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ABCA5-49R-B | Recombinant Rat ABCA5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
ABCA5 involved in several pathways and played different roles in them. We selected most pathways ABCA5 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCC1,Abcb1b,SUR2A,ABCD3A,ABCB1LB,ABCA3,ABCC4,ABCA4,ABCC8,ABCB7 |
Protein Function
ABCA5 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA5 itself. We selected most functions ABCA5 had, and list some proteins which have the same functions with ABCA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity | ABCG2D,ABCD3A,KIF6,VCP,KIF23,KIF7,HLTF,KIF4,PSMC2,HSPD1 |
| transporter activity | LCN2,ABCA9,SLC12A10.1,APODB,SLC23A1,APODA.2,HIAT1B,AP1G1,Abca2,SLC15A5 |
| ATP binding | NLRC3,Atp8a2,NTRK3,GC2,ABCD3A,DDX6,MAP4K4,UBE2G2,MOK,HSP90AA1.2 |
| nucleotide binding | MAPKAPK2B,CSF1RA,GC2,MXB,ACSL1,RBM24,ABCG2D,MAP3K12,PTBP1B,SF3B14 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC8,Abca2,ABCG5,ABCB1A,ABCB4,ABCA1B,ABCB6,ABCC11,ABCD3A,ABCC6 |
Interacting Protein
ABCA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA5.
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References
- Gao, YY; Li, W; et al. Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells. MOLECULAR MEDICINE REPORTS 11:2118-2124(2015).
- Thiel, CS; Hauschild, S; et al. Identification of Reference Genes in Human Myelomonocytic Cells for Gene Expression Studies in Altered Gravity. Biomed Research International :-(2015).
