ABCA4
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 4 -
Overview
ATP-binding cassette, sub-family A (ABC1), member 4, also known as ABCA4 or ABCR, is a protein which in humans is encoded by the ABCA4 gene. -
Synonyms
FFM;RMP;ABCR;RP19;STGD;ABC10;ARMD2;CORD3;STGD1;FLJ17534;DKFZp781N1972;retinal-specific ATP-binding cassette transporter
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABCA4-033H | Recombinant Human ABCA4 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ABCA4-1080M | Recombinant Mouse ABCA4 Protein | Mammalian Cell | Mouse | His |
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| ABCA4-8115H | Recombinant Human ABCA4 protein, His & T7-tagged | E.coli | Human | His&T7 | Gly1398~Asn1727 |
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| ABCA4-0607H | Recombinant Human ABCA4 Protein (Gly1398-Asn1727), N-His-tagged | E.coli | Human | His | Gly1398-Asn1727 |
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| ABCA4-182M | Recombinant Mouse ABCA4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ABCA4-182M-B | Recombinant Mouse ABCA4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ABCA4 involved in several pathways and played different roles in them. We selected most pathways ABCA4 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCA3,ABCD3,ABCA9,ABCB9,ABCC12,ABCC1,ABCC11,TAP1,ABCB1,ABCA7 |
Protein Function
ABCA4 has several biochemical functions, for example, ATP binding,ATPase activity,ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA4 itself. We selected most functions ABCA4 had, and list some proteins which have the same functions with ABCA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipid-translocating ATPase activity | ATP8B5,ATP8B1,ATP8A1,ATP9A,ATP8B3,Atp8a2,ATP11C,ATP11A,ATP9B,ATP10A |
| ATPase activity, coupled to transmembrane movement of substances | ABCA4A,ABCC5,ABCA6,ABCC9,ABCA1,ABCB4,TAP1,ABCG2D,ABCC11,ABCA5 |
| cholesterol transporter activity | APOE,ABCA1,ABCA4A,APOEA,STAR,APOA4A,APOEB,ABCA13,APOB,APOA1A |
| transporter activity | TMEM184C,SLC2A11L,HIAT1B,TMEM184BA,SLC25A38B,MFSD10,SLCO1F2,FABP11A,RBP5,CPNE7 |
| ATP binding | UBE2W,ABCG3,KATNA1,UPF1,NTRK3,CDK16,MKNK2A,GAK,MYH9A,ATPBD4 |
| nucleotide binding | CPSF6,RHOGA,HRASA,DHX34,HTATSF1,CRCP,HUG,BMPR2A,HNRNPH3,SNRPB2 |
| phospholipid transporter activity | MTTP,OSBPL8,ABCA4A,MFSD2A,ABCG1,ABCA1B,MFSD2AB,ABCA7,ATP8B5,APOA1 |
| ATPase activity | PSMC5,BLM,ABCD3B,KIF22,KIF23,ABCB6,ABCA4A,ABCC8,ATP13A3,ATAD2B |
Interacting Protein
ABCA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA4.
Resources
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References
- Grassmann, F; Bergholz, R; et al. Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy). BMC OPHTHALMOLOGY 15:-(2015).
- Puntel, A; Maeda, A; et al. Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. BIOMATERIALS 44:103-110(2015).
