ABCA1

  • Official Full Name

    ATP-binding cassette, sub-family A (ABC1), member 1

  • Overview

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency.

  • Synonyms

    ABCA1;ATP-binding cassette, sub-family A (ABC1), member 1;ABC1, HDLDT1;ATP-binding cassette sub-family A member 1;Tangier disease;TGD;membrane-bound;ATP-binding cassette transporter 1;ATP-binding cassette transporter A1;cholesterol efflux regulat

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Wheat Germ
  • E.Coli/Yeast
  • Mammalian Cells
  • Insect Cells
  • HEK293
  • His
  • GST
  • Flag
  • Strep II
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ABHD10-9232H Recombinant Human ABHD10 protein, His-tagged E.coli Human His 1-306 aa
ALKBH4-9585H Recombinant Human ALKBH4 protein, GST-tagged E.coli Human GST 1-302 aa
ABCA1-178H Recombinant Human ABCA1 protein, GST-tagged Wheat Germ Human GST 86-185 a.a.
ABCA1-3696M Recombinant Mouse ABCA1, His-tagged E.coli Mouse His 2261
Abca1-3728M Recombinant Mouse Abca1, His-tagged E.Coli/Yeast Mouse His 2261
ABCA1-459H Recombinant Human ABCA1 Mammalian Cells Human His
ABCA1-5721C Recombinant Chicken ABCA1 Mammalian Cells Chicken His
ABCA1-5857H Recombinant Human ABCA1 protein, His-tagged E.coli Human His Asn1385~Phe1663
ABCA1-0185H Recombinant Human ABCA1 Protein (Ser45-Glu271), N-His-tagged E.coli Human His Ser45-Glu271
ABCA1-0286H Recombinant Human ABCA1 Protein (A2-V2261), Flag, Strep II, 8×His tagged Insect Cells Human Flag&His&Strep II A2-V2261
ABCA1-10H Recombinant Human ABCA1 Protein, His-tagged E.coli Human His Arg43-Glu450
ABCA1-2398H Recombinant Human ABCA1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ABCA1-2398H-B Recombinant Human ABCA1 Protein Pre-coupled Magnetic Beads HEK293 Human
ABCA1-2493H Recombinant Human ABCA1 protein(1171-1280 aa), C-His-tagged E.coli Human His 1171-1280 aa

    Involved Pathway

    ABCA1 involved in several pathways and played different roles in them. We selected most pathways ABCA1 participated on our site, such as ABC transporters,Fat digestion and absorption,Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid, triacylglycerol, and ketone body metabolism SREBF2,Agmo,APOA5,CPT1B,SLC25A1A,ACOT9,CTGF,AGPAT1,ACOT11,AGPAT6
    ABC transporters ABCA1B,ABCD4,ABCG1,ABCD1,ABCA7,SUR2A,Abca2,ABCB9,ABCG3,ABCC12
    Folate Metabolism SAA2,SAA4,SAA1,SAA2-SAA4,AHCY
    Fat digestion and absorption SCARB1,PNLIPRP2,FABP2,PLA2G2F,LIPF,DGAT2,CD36,PNLIPRP1,PLA2G3,ACAT2
    Metabolism SGMS2,SLC16A8,APOEA,CBLC-1,NUDT3,TIMMDC1,GLIPR1,PDK3,SULT1ST6,UCP2
    HDL-mediated lipid transport BMP1A,AMN,Alb,APOA1B,APOC2,CETP
    Lipid digestion, mobilization, and transport APOC2,APOA1B,FABP12,FABP9,Alb,FABP11A,APOA4A,APOA4B.1,CLPS,LMF1
    Lipoprotein metabolism APOA5,APOA4B.2,CETP,APOEB,APOC2,APOBB.1,APOA4B.1,LPA,APOF,APOA1B

    Protein Function

    ABCA1 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA1 itself. We selected most functions ABCA1 had, and list some proteins which have the same functions with ABCA1. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding ENSA,HMGCL,Ar,FGF11A,MPV17L,CCDC129,CDH5,GDNF,SERPINE1,CTNND1
    apolipoprotein A-I binding ABCA1B,SCARB1,LCAT
    ATPase binding Ar,ANK2,FXYD4,NR1H2,NKAIN1,SVIP,ATP6V0A1A,S100A1,NOP58,FAM119A
    apolipoprotein A-I receptor activity ABCA7
    ATP binding EPHA10,MYH4,AKT1,HSPA6,AK9,CAMK1GA,ASS1,P2RX8,PBK,PAICS
    small GTPase binding FGD3,TSC2,ERRFI1,PEX5L,RNF152,FGD4,FGD5,FGD1,FGD2,FLNA
    ATPase activity, coupled to transmembrane movement of substances ABCG2,ABCC5,ABCB1,TAP1,ABCA8,ABCC10,ABCB6A,ATP6V1D,ABCD3B,ABCC11
    cholesterol transporter activity APOA1,ABCA1B,ABCG1,APOA4B.1,APOEB,STAR,ABCA13,ABCA7,APOA4,ABCA4
    syntaxin binding PLDN,VPS52,HECTD3,RAB11A,SYTL1,GOLGA2,BET1,SYT1A,TMED9,TXLNG

    Interacting Protein

    ABCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA1.

    MYC

    Resources

    Research Area

    Lipid and Fatty Acid Transport
    Uptake and Transport Molecules on Endothelial Cells
    Uptake and Transport Molecules in VSMC
    Eicosanoids and Regulators

    References

    • Tomkin, GH; Owens, D; et al. Investigational therapies for the treatment of atherosclerosis. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:1411-1421(2014).
    • Nicod, N; Parker, RS; et al. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 26:165-172(2015).

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