AASS

  • Official Full Name

    aminoadipate-semialdehyde synthase

  • Overview

    This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.

  • Synonyms

    AASS;aminoadipate-semialdehyde synthase;alpha-aminoadipic semialdehyde synthase, mitochondrial;LKRSDH;LORSDH;lysine-2-oxoglutarate reductase;aminoadipic semialdehyde synthase;alpha-aminoadipate semialdehyde synthase;lysine-ketoglutarate reductase

Recombinant Proteins

  • Human
  • Rat
  • Bovine
  • Zebrafish
  • Mouse
  • E. coli
  • E.Coli or Yeast
  • Mammalian Cell
  • E.coli
  • HEK293
  • N-His
  • His
  • His&T7
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ALG14-9574H Recombinant Human ALG14 protein, His-tagged E. coli Human N-His 27-216 aa
Aass-3339R Recombinant Rat Aass, His-tagged E.Coli or Yeast Rat His 926
AASS-3340B Recombinant Bovine AASS, His-tagged E.Coli or Yeast Bovine His 926
AASS-390R Recombinant Rat AASS Protein Mammalian Cell Rat His
AASS-7710Z Recombinant Zebrafish AASS Mammalian Cell Zebrafish His
Aass-8112M Recombinant Mouse Aass protein, His & T7-tagged E.coli Mouse His&T7 Met477~Leu926
AASS-0180H Recombinant Human AASS Protein (Val33-Leu455), N-His-tagged E.coli Human His Val33-Leu455
AASS-45R Recombinant Rat AASS Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
AASS-45R-B Recombinant Rat AASS Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    AASS involved in several pathways and played different roles in them. We selected most pathways AASS participated on our site, such as Adherens junction,Amoebiasis,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with AASS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal adhesion MAPK10,MYLPFA,MAPK8,PPP1CBL,THBS1,MYL10,PIK3R3B,ITGA3,COL27A1,MYLK2
    Adherens junction TGFBR2,CTNNB1,WAS,MLLT4,PVRL4,PTPN6,LMO7A,MAPK3,SMAD4,RAC3
    Leukocyte transendothelial migration CLDN2,CLDN17,PIK3R2,CLDN16,MYL12B,PIK3CD,CTNNA3,CDH5,ITGB1,CYBA
    Amoebiasis COL4A4,COL1A2,TLR4,PLCB1,COL1A1,PRKACA,SERPINB6,ITGB2,CXCL8,TLR2
    Hemostasis GATA2,HBG1,SLC3A2B,CD9B,CABLES1,MFN2,DOCK8,CFHL2,DOCK6,ANXA2B
    Platelet activation, signaling and aggregation ABHD6B,PRKCHB,C6orf25,WDR1,G6b,GAS6,MMRN1,BRPF3,TFA,MMRN2A
    Platelet degranulation SCG3,IGF2B,CAP1,SERPINF2B,CD9A,MMRN2A,MMRN1,HRG,WDR1,PLEK
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGB4,ATP2A2,ACTN4,ITGA7,RYR2,CACNB4,SGCG,CACNA2D1,JUP,ITGA5

    Protein Function

    AASS has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,actin filament binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AASS itself. We selected most functions AASS had, and list some proteins which have the same functions with AASS. You can find most of the proteins on our site.

    Function Related Protein
    ion channel binding AKAP9,FXYD1,DLG1,ACTN2,ARRB1,LYN,FHL1,PACS2,ACTN3,SCN5A
    ligand-dependent nuclear receptor transcription coactivator activity HMGA1-RS1,PPARGC1A,RBM14,SMARCD3,ZCCHC12,CCDC62,ATXN7L3,TADA3,ACTN4,NCOA1
    chromatin DNA binding H2AFZ,MED1,HIST1H1C,THRB,RXRA,H1F0,FOXC2,RELA,VAX2,MYOD1
    calcium ion binding PCDHB15,MYL6,ANXA11B,LTBP1,UMODL1,MYL7,RCV1,MYL2B,OCM,PCDHGC3
    retinoic acid receptor binding MED25,PRAMEF2,NSD1,LRIF1,MED1,ASXL1,HMGA1,SNW1,PRAME,HMGA1-RS1
    actin filament binding LASP1,SVIL,AIF1L,NEXN,SYNE2,FSCN2B,ARPC1A,SLC6A4,SHROOM1,SYNE3
    poly(A) RNA binding SPATS2L,RPL15,RTCA,RPF1,LRP1,CCT3,ATP5A1,EIF5,HELZ,HIST1H4L
    RNA polymerase II regulatory region sequence-specific DNA binding ZBTB11,ZSCAN2,PKNOX2,RXRG,ALX1,SP5,BCL6A,AIRE,TBX20,ZFP583
    nucleoside binding ACTN4,POLA1,CDA,PNP

    Interacting Protein

    AASS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AASS here. Most of them are supplied by our site. Hope this information will be useful for your research of AASS.

    Resources

    References

    • Gatrell, SK; Berg, LE; et al. Tissue distribution of indices of lysine catabolism in growing swine. JOURNAL OF ANIMAL SCIENCE 91:238-247(2013).

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