ZRSR2
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Official Full Name
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -
Overview
This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3 splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. -
Synonyms
ZRSR2;zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2;U2 small nuclear RNA auxiliary factor 1 like 2 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 2 , U2AF1L2;U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2;U2AF1 RS2;URP;CCCH type zinc finger, RNA binding motif and serine/arginine rich protein 2;MGC142014;MGC142040;Renal carcinoma antigen NY REN 20;U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit related protein 2;U2(RNU2) small nuclear RNA auxiliary factor 1 like 2;U2AF1L2;U2AF1RS2;U2AF35-related protein;renal carcinoma antigen NY-REN-20;U2(RNU2) small nuclear RNA auxiliary factor 1-like 2;U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2;CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2;U2AF1-RS2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZRSR2-9189HCL | Recombinant Human ZRSR2 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
ZRSR2 involved in several pathways and played different roles in them. We selected most pathways ZRSR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZRSR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ZRSR2 has several biochemical functions, for example, metal ion binding,nucleotide binding,pre-mRNA 3-splice site binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZRSR2 itself. We selected most functions ZRSR2 had, and list some proteins which have the same functions with ZRSR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZIM3,SUZ12,PPP1CB,DNMT3B,CCDC76,SETDB1A,ZNF165,NQO2,ZNHIT1,RAF1B |
| pre-mRNA 3-splice site binding | U2AF2,SLU7 |
| protein binding | AKAP9,MC1R,TTC33,APBB2,NEGR1,DUSP5,NFATC4,PSMA7,S100A1,DYRK4 |
| nucleotide binding | CAMK2D1,ACTA1B,RBM15,PABPC1B,PAK2B,NT5M,SRSF6B,SETD1BA,LEMD3,GM4922 |
Interacting Protein
ZRSR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZRSR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZRSR2.
SRPK2;CLK2;SDCBP2;SSX2IP;SRPK1;STK4;EMC2;Sidt2
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References
- Lindsley, RC; Mar, BG; et al. Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. BLOOD 125:1367-1376(2015).
- Madan, V; Kanojia, D; et al. Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. Nature Communications 6:-(2015).
