ZNF473
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Official Full Name
zinc finger protein 473 -
Overview
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. -
Synonyms
ZNF473;zinc finger protein 473;ZN473;HZFP100;zfp-100;zinc finger protein ZFP100;zinc finger protein 100 homolog;Zfp 100;ZNF 473;4932441F21;D030014N22Rik
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZFP473-18953M | Recombinant Mouse ZFP473 Protein | Mammalian Cell | Mouse | His |
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| ZNF473-5333R | Recombinant Rhesus monkey ZNF473 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ZNF473-2033HCL | Recombinant Human ZNF473 cell lysate | Human | Non |
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| ZNF473-10429M | Recombinant Mouse ZNF473 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ZNF473-10429M-B | Recombinant Mouse ZNF473 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ZNF473-301199H | Recombinant Human ZNF473 protein, GST-tagged | E.coli | Human | GST | Met1-Glu204 |
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| ZNF473-5146R | Recombinant Rhesus Macaque ZNF473 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ZNF473-5146R-B | Recombinant Rhesus Macaque ZNF473 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ZNF473-582H | Recombinant Human ZNF473 Protein, His-tagged | E.coli | Human | His |
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Involved Pathway
ZNF473 involved in several pathways and played different roles in them. We selected most pathways ZNF473 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNF473 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Processing of Capped Intronless Pre-mRNA | LSM10,CSTF1,CSTF3,LSM11,CLP1,SLBP,CSTF2,PAPOLA,ZFP473,NUDT21 |
| RNA Polymerase II Transcription | NELFE,NUDT21,PAPOLA,CCNT2B,CLP1,SSRP1A,CSTF1,GM3258,SUPT16H,RNPS1 |
| Cleavage of Growing Transcript in the Termination Region | THOC4,CSTF2,NUDT21,RNPS1,U2AF2,CSTF3,SRSF11,CLP1,LSM11,CSTF1 |
| SLBP independent Processing of Histone Pre-mRNAs | LSM10,ZFP473,LSM11 |
| Gene Expression | ZNF688,GTF3C3,ZNF573,HBXIP,NSUN2,GM3258,FARSB,ZNF773,EEF1B2,ZNF311 |
| Generic Transcription Pathway | RRAGB,PSTPIP2,ZFP37,ZKSCAN4,ZNF565,ZNF577,NR5A1A,ZNF274,ZNF776,ZNF620 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | LSM11,LSM10,ZFP473,SLBP |
| RNA Polymerase II Transcription Termination | RNPS1,THOC4,SRSF11,CSTF1,LSM11,PAPOLA,SLBP,CLP1,LSM10,ZFP473 |
Protein Function
ZNF473 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNF473 itself. We selected most functions ZNF473 had, and list some proteins which have the same functions with ZNF473. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | DTD1,CSNK2B,Itga10&Itgb1,TRIM41,RXRAA,ZFP13,ZNF550,KLF12A,CIAPIN1,FYNB |
| protein binding | NINJ1,C2orf50,PIAS2,EIF3C,RAB1B,ARF1,SHOX,NECAB2,ARL6IP4,HELT |
| DNA binding | TAF4B,TBPL1,GM239,DNMT3A,SMTNL,SRRT,CHD2,SLC2A4RG,ZFY1,ARID3C |
Interacting Protein
ZNF473 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNF473 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNF473.
RNPS1;ZSCAN12;ZNF250;CLK2;KRTAP10-8;KRTAP10-9;ZNF792
Resources
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References
- Hu, C; Zhang, SP; et al. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. JOURNAL OF BIOLOGICAL CHEMISTRY 287:18937-18952(2012).
- White, D; Rafalska-Metcalf, IU; et al. The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation. MOLECULAR CANCER RESEARCH 10:401-414(2012).
