ZNF274
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Official Full Name
zinc finger protein 274 -
Overview
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. -
Synonyms
ZNF274;zinc finger protein 274;neurotrophin receptor-interacting factor homolog;ZKSCAN19;SP2114;Zf2;Zinc finger protein HFB101;Zinc finger protein with KRAB and SCAN domains 19;Zinc finger protein zfp2;KRAB zinc finger protein HFB101;HFB101
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZNF274-1100C | Recombinant Cynomolgus ZNF274 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| ZNF274-234H | Recombinant Human ZNF274 Protein, His-tagged | E.coli | Human | His |
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| ZNF274-106HCL | Recombinant Human ZNF274 293 Cell Lysate | HEK293 | Human | Non |
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| ZNF274-842C | Recombinant Cynomolgus Monkey ZNF274 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| ZNF274-842C-B | Recombinant Cynomolgus Monkey ZNF274 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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Involved Pathway
ZNF274 involved in several pathways and played different roles in them. We selected most pathways ZNF274 participated on our site, such as Gene Expression,Generic Transcription Pathway,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNF274 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | ZIM3,IPO8,CCNC,POU2F1B,ZNF155,MBD3,APOBEC1,RRAGA,PRPF8,TET1 |
| Generic Transcription Pathway | ZNF468,ZNF764,ZNF480,ZNF599,NR2E3,NRBF2B,MED7,ZNF18,TRIM33,ZNF705A |
| Neurotrophin signaling pathway | MATK,RIPK2,PIK3CD,RAP1A,MAPK9,PTPN11,MAP3K1,MAP3K5,MAPK10,CAMK4 |
| p75(NTR)-mediated signaling | PRDM4,BEX1,MAGEH1,RTN4,OMG,NDN,RTN4R |
Protein Function
ZNF274 has several biochemical functions, for example, metal ion binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNF274 itself. We selected most functions ZNF274 had, and list some proteins which have the same functions with ZNF274. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | PAPL,PDLIM3B,ARID2,KLF13,RYBPB,ISL2B,RFPL4,ACVR2B,CYCS,ADSSL |
| transcription corepressor activity | RYBP,SSX3,TSG101,HEYL,AEBP2,CCAR1,PEX14,WWTR1,APEX1,ZHX1 |
| transcription factor activity, sequence-specific DNA binding | ZNF227,TBX2A,ZNF79,EGR1,ZNF668,ATF3,RORAB,FOXQ1A,ZFHX3,FOXI3A |
| sequence-specific DNA binding | FOXQ2,NR4A2B,PRDM16,PRRXL1,FOXI3A,FOXO1,DLX5A,NR2F1A,LBX1,KLF5 |
| protein binding | GLS,ZFPL1,SLC52A2,RBM17,XRCC3,TK1,RAVER2,VDAC2,PRICKLE1,RAD9B |
Interacting Protein
ZNF274 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNF274 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNF274.
GRB2;CBX5
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References
- Williams, HJ; Norton, N; et al. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. MOLECULAR PSYCHIATRY 16:429-441(2011).
- Jolodar, A; Seghatoleslami, S; et al. Identification of a cDNA sequence coding for kruppel-like factor 2b (Klf2b) from the skin mucosa of common carp (Cyprinus carpio). IRANIAN JOURNAL OF VETERINARY RESEARCH 12:150-155(2011).
