ZNF189
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Official Full Name
zinc finger protein 189 -
Overview
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable;number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 (PubMed;9653648)). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box;(KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is;present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always;present. -
Synonyms
ZNF189;zinc finger protein 189;BB131811;C430015I23Rik
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZNF189-5308R | Recombinant Rhesus monkey ZNF189 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ZNF189-1991HCL | Recombinant Human ZNF189 cell lysate | Human | Non |
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| ZNF189-301189H | Recombinant Human ZNF189 protein, GST-tagged | E.coli | Human | GST | Met1-Ile150 |
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| ZNF189-5121R | Recombinant Rhesus Macaque ZNF189 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ZNF189-5121R-B | Recombinant Rhesus Macaque ZNF189 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ZNF189 involved in several pathways and played different roles in them. We selected most pathways ZNF189 participated on our site, such as Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNF189 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | ZNF710,ZNF133,TUBB3,NR1I2,ZNF557,ZNF548,NR2F6,GLS2B,NR2C2,COX14 |
| Gene Expression | DNMT1,NUDT21,PHF1,TET2,ZNF43,MED31,ZNF624,ZNF792,ZFP1,ZFP36L1 |
Protein Function
ZNF189 has several biochemical functions, for example, DNA binding,metal ion binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNF189 itself. We selected most functions ZNF189 had, and list some proteins which have the same functions with ZNF189. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SP110,EGR2B,DRAP1,ZNF443,ELMSAN1A,FOXF2A,FOXC1B,TOX4,ZNF239,RAD51B |
| transcription factor activity, sequence-specific DNA binding | HOXA4,FOXK2,ZNF454,ATF6,SMAD6,RORA,TP63,ZIK1,DMRTC2,BRD8 |
| metal ion binding | RNF17,AOX4,TRIM35-30,TOE1,POLR2A,GALNTL2,PLEKHF2,ZNF10,TIMP3,ELAC2 |
Interacting Protein
ZNF189 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNF189 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNF189.
AURKA;BUB1;KRAS;ERBB2;SRC;BRAF;MCC;CTNNA1;BMPR1A;PMS2;SMAD4;STK11;DLC1;AXIN2
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References
- Punwani, D; Simon, K; et al. Transcription Factor Zinc Finger and BTB Domain 1 Is Essential for Lymphocyte Development. JOURNAL OF IMMUNOLOGY 189:1253-1264(2012).
- Kolattukudy, PE; Niu, JL; et al. Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway. CIRCULATION RESEARCH 110:174-189(2012).
