ZKSCAN1
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Official Full Name
zinc finger with KRAB and SCAN domains 1 -
Overview
The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger;proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences,;called H/C links (summarized by Tommerup and Vissing, 1995 (PubMed 7557990)). Transcriptional regulatory proteins;containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular;proliferation and differentiation. See ZNF91 (MIM 603971) for general information on zinc finger proteins. -
Synonyms
ZKSCAN1;zinc finger with KRAB and SCAN domains 1;zinc finger protein 36 (KOX 18) , ZNF36, ZNF139;zinc finger protein with KRAB and SCAN domains 1;KOX18;PHZ 37;MGC138429;MGC63357;Zinc finger protein 139;Zinc finger protein 36 (KOX 18);Zinc finger protein 36;Zinc finger protein KOX18;ZKSC1_HUMAN;ZNF139;ZNF36;PHZ-37;9130423L19Rik
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
ZKSCAN1 involved in several pathways and played different roles in them. We selected most pathways ZKSCAN1 participated on our site, such as Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZKSCAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | HNRNPH2,ELAC2,ZNF670,TDRD1,ZNF566,HUG,NR2F6B,PLD6,GTF3AB,ZNF12 |
| Generic Transcription Pathway | NR6A1,ZNF614,ZNF230,ZNF705A,ZNF302,ZNF738,NR6A1A,ZNF621,TBX5A,COX5B |
Protein Function
ZKSCAN1 has several biochemical functions, for example, metal ion binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZKSCAN1 itself. We selected most functions ZKSCAN1 had, and list some proteins which have the same functions with ZKSCAN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CAV2,GRHL2,APOA4,NXF3,TNS1,NAT10,LYRM2,BANP,FTH1,CEBPG |
| metal ion binding | WT1A,TSSK5,GUCA1D,PFKL,ZFP90,ZNF100,PDLIM3B,LMAN1,WBSCR17,LMO7A |
| transcription factor activity, sequence-specific DNA binding | ZKSCAN17,FOXP1A,GABPB1,RXRGA,ZFP2,HOXB3,ZFP516,ZFP287,ETV5B,ZFP14 |
| sequence-specific DNA binding | RARGB,NKX2.7,NR1H5,DMRT2,HNF4G,DBPB,MSXA,EN2,CDX1B,BSX |
Interacting Protein
ZKSCAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZKSCAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZKSCAN1.
ZSCAN32
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References
- Zhang, Y; Lu, TL; et al. Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population. PLOS ONE 8:-(2013).
- Liang, Y; Hong, FH; et al. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206. NUCLEIC ACIDS RESEARCH 40:8721-8732(2012).
