ZIC4
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Official Full Name
Zic family member 4 -
Overview
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. -
Synonyms
ZIC4;Zic family member 4;zinc finger protein of the cerebellum 4;zinc finger protein ZIC 4;zinc family member 4 protein HZIC4;FLJ42609;FLJ45833
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZIC4-4505Z | Recombinant Zebrafish ZIC4 | Mammalian Cell | Zebrafish | His |
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| ZIC4-164HCL | Recombinant Human ZIC4 293 Cell Lysate | HEK293 | Human | Non |
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| ZIC4-5945H | Recombinant Human ZIC4 protein, His&His-tagged | E.coli | Human | His | 1-334aa |
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Involved Pathway
ZIC4 involved in several pathways and played different roles in them. We selected most pathways ZIC4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ZIC4 has several biochemical functions, for example, DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC4 itself. We selected most functions ZIC4 had, and list some proteins which have the same functions with ZIC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF433,SCRT1A,ZNF521,HCCS,TGM4,ZNF471,AGFG1B,GRIN2A,CMTM2A,KEL |
| DNA binding | EN2,MNDA,RORCA,TET2,FOXI3A,OTUD7B,SP4,RYBP,RORC,HOXD10A |
Interacting Protein
ZIC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC4.
ZNF598;CCDC93
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References
- Honnorat, J; et al. Therapeutic approaches in antibody-associated central nervous system pathologies. REVUE NEUROLOGIQUE 170:587-594(2014).
- Dahm, L; Ott, C; et al. Seroprevalence of Autoantibodies against Brain Antigens in Health and Disease. ANNALS OF NEUROLOGY 76:82-94(2014).
