ZIC3

  • Official Full Name

    Zic family member 3

  • Overview

    This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.

  • Synonyms

    ZIC3;Zic family member 3;heterotaxy 1 , HTX1, Zic family member 3 (odd paired homolog, Drosophila);zinc finger protein ZIC 3;HTX;ZNF203;heterotaxy 1;zinc finger protein 203;zinc finger protein of the cerebellum 3;Zic family member 3 (odd-paired
Cat.# Product name Source (Host) Species Tag Protein Length Price
ZIC3-19178M Recombinant Mouse ZIC3 Protein Mammalian Cells Mouse His
ZIC3-270Z Recombinant Zebrafish ZIC3 Mammalian Cells Zebrafish His
ZIC3-165HCL Recombinant Human ZIC3 293 Cell Lysate HEK293 Human Non
ZIC3-10380M Recombinant Mouse ZIC3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ZIC3-10380M-B Recombinant Mouse ZIC3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ZIC3-438H Recombinant Human ZIC3 Protein, His-tagged E.coli Human His

    Involved Pathway

    ZIC3 involved in several pathways and played different roles in them. We selected most pathways ZIC3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells AXIN1,PAX6,ACVR1B,WNT2B,PIK3R5,ID2,NODAL,WNT11,AKT2,IGF1

    Protein Function

    ZIC3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC3 itself. We selected most functions ZIC3 had, and list some proteins which have the same functions with ZIC3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PRPF40A,FAM50B,TFPT,PUM1,VARS,OLFM2,POLD1,PVR,PER2,CBX8
    RNA polymerase II core promoter proximal region sequence-specific DNA binding PDX1,CUX2,PPARA,IRF4,RFX8,HHEX,ZNF680,KLF17,ZNF100,CTCF
    transcription factor activity, sequence-specific DNA binding ZNF131,ZNF187,STAT2,TCF7L1B,FOXA1,RXRAB,SIM1A,ZNF567,ETS1,E2F4
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TRP53,PITX2,POU4F1,NR6A1,RBPJ,NR3C1,GCM1,FOXI1,WT1,NR2E1
    sequence-specific DNA binding BATF,DLX6,HOXD10A,PPARGC1A,NR2F1,TSNAX,HOXB1A,HMX2,ZKSCAN1,ATF7
    metal ion binding RBM4.2,AOX4,ZC4H2,ZMIZ2,C22orf28,ZBTB8B,SEC23IP,PPP2CB,ZNF576,XGB

    Interacting Protein

    ZIC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC3.

    TP53;CTNNB1;TWIST1

    Resources

    Research Area

    Somite Markers
    Neural Stem Cell Transcription Factors
    Embryonic and Induced Pluripotent Stem Cell Markers

    References

    • Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).

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