ZIC2
-
Official Full Name
zinc finger protein of the cerebellum 2 -
Overview
ZIC2 (zinc finger protein of the cerebellum 2) is a transcriptional repressor and may regulate tissue specific expression of the dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain. -
Synonyms
Zic2;zinc finger protein of the cerebellum 2;Ku;HPE5;zinc finger protein ZIC 2;kumba;GENA 29;OTTMUSP00000022013;odd-paired homolog;Zic family member 2 (odd-paired homolog, Drosophila);Zinc Finger Protein of Cerebellum 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZIC2-166HCL | Recombinant Human ZIC2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| ZIC2-1416H | Recombinant Human ZIC2 protein, His-tagged | E.coli | Human | His | 100-415aa |
|
| ZIC2-2492H | Recombinant Human ZIC2 protein(271-450 aa), C-His-tagged | E.coli | Human | His | 271-450 aa |
|
| ZIC2-439H | Recombinant Human ZIC2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| Zic2-7109M | Recombinant Mouse Zic2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| ZIC2-774H | Recombinant Human ZIC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
Involved Pathway
ZIC2 involved in several pathways and played different roles in them. We selected most pathways ZIC2 participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog signaling pathway | CSNK1A1L,WNT2,PRKACG,IHHB,WNT11R,HHIP,PTCH1,WNT7A,GLI1,WNT10B |
Protein Function
ZIC2 has several biochemical functions, for example, DNA binding,chromatin DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC2 itself. We selected most functions ZIC2 had, and list some proteins which have the same functions with ZIC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin DNA binding | SMAD3,GATA1,HIST1H1E,HIST1H1A,NEUROG3,RELA,INSM1A,XBP1,FOXC2,SLAMF7 |
| DNA binding | E2F5,MIXL1,HIST1H4A,TFB1M,HIST1H2BM,HMGB1A,NKX2-6,POLE2,ZNF786,ZFP35 |
| metal ion binding | MARCH9,ELAC1,ZNF292A,NR4A2A,LNX2A,PAK3,PNKD,RORCB,HMOX1,ZNF683 |
| transcription factor activity, sequence-specific DNA binding | TAF5L,HSFX1,E2F3,ZNF484,ZNF19,RBPJ,ESR2A,ZFP367,FOXD1L,FLI1A |
Interacting Protein
ZIC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC2.
PRKDC
Resources
Related Services
Related Products
References
- Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).
- Sakuma, K; Kasamatsu, A; et al. Expression status of Zic family member 2 as a prognostic marker for oral squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136:553-559(2010).
