ZBTB4
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Official Full Name
zinc finger and BTB domain containing 4 -
Overview
Kaiso is a member of the POZ-zinc finger family of transcription factors implicated in development and cancer. It acts as a DNA methylation-dependent transcriptional repressor. Kaiso is a dual specificity DNA-binding protein that recognizes the specific c -
Synonyms
ZBTB4;zinc finger and BTB domain containing 4;zinc finger and BTB domain-containing protein 4;KAISO L1;KIAA1538;ZNF903;KAISO-like zinc finger protein 1;KAISO-L1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZBTB4-3782H | Recombinant Human ZBTB4, His-tagged | E.coli | Human | His | 1-353aa | |
| ZBTB4-3783H | Recombinant Human ZBTB4 protein, GST-tagged | E. coli | Human | GST | 1-353 aa |
|
Involved Pathway
ZBTB4 involved in several pathways and played different roles in them. We selected most pathways ZBTB4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ZBTB4 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,metal ion binding,methyl-CpG binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB4 itself. We selected most functions ZBTB4 had, and list some proteins which have the same functions with ZBTB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | Bcl2a1b,MTMR2,MIXL1,ADAM10,ATP2A1,PRKG2,GSTM3,XDH,DMRTC2,MUC13 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ATF2,RARA,BHLHA15,MYOD1,SATB1,RELB,HOXD8,CEBPB,ZNF812,AIRE |
| methyl-CpG binding | ZNF295,MBD3,MBD1,MBD1B,MECP2,MBD3B,MBD3A,DNMT1,MBD3L1,UHRF1 |
| metal ion binding | PRG4B,CEPT1,FTR14,ZC3H18,ZBTB16,PCXB,CASZ1,TRIM35-36,BCL11AA,NUDT10 |
| protein binding | SNRPN,RHOXF2,UBE2F,PCP4,NAP1L4,EZH2,PDIA6,NADK,TRAM1,TCEAL5 |
| protein kinase binding | FOXO3,GOLGA2,ADCY6,PIFO,RPS3,TPRKB,SMAD1,FBXO7,PTPN6,PRKAG2 |
| sequence-specific DNA binding | ERG,BHLHE22,SMAD3,SOX14,SCAND2P,VSX2,ATF4B2,POU3F2A,SOX13,FOXH1 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | ETV3,ZBTB12.2,VAX1,E4F1,ARID5B,FOXO3,HMX1,DMBX1,SATB1,ETV6 |
Interacting Protein
ZBTB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB4.
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References
- Bernard, D; Bedard, M; et al. Structural and dynamical characterization of the Miz-1 zinc fingers 5-8 by solution-state NMR. JOURNAL OF BIOMOLECULAR NMR 57:103-116(2013).
- Gao, JX; Liu, T; et al. Insertional Mutagenesis and Cloning of the Gene Required for the Biosynthesis of the Non-Host-Specific Toxin in Cochliobolus lunatus that Causes Maize Leaf Spot. PHYTOPATHOLOGY 104:332-339(2014).
