ZBTB33

  • Official Full Name

    zinc finger and BTB domain containing 33

  • Overview

    This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

  • Synonyms

    ZBTB33;zinc finger and BTB domain containing 33;transcriptional regulator Kaiso;kaiso;WUGSC:H_DJ525N14.1;ZNF kaiso;ZNF348;Kaiso protein;Kaiso transcription factor;KAISO_HUMAN;ZBTB 33;Zinc finger and BTB domain-containing protein 33;Zinc finger transcription factor Kaiso;ZNF 348;OTTHUMP00000023933;OTTHUMP00000245265;ZNF-kaiso

Recombinant Proteins

  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Human
  • Mammalian Cell
  • Wheat Germ
  • E. coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ZBTB33-3562C Recombinant Chicken ZBTB33 Mammalian Cell Chicken His
ZBTB33-5258R Recombinant Rhesus monkey ZBTB33 Protein, His-tagged Mammalian Cell Rhesus macaque His
ZBTB33-5815Z Recombinant Zebrafish ZBTB33 Mammalian Cell Zebrafish His
ZBTB33-1954HCL Recombinant Human ZBTB33 cell lysate Human Non
ZBTB33-220H Recombinant Human ZBTB33 Protein, GST-tagged Wheat Germ Human GST
ZBTB33-22H Recombinant Human ZBTB33 protein, His-tagged E. coli Human His Leu101-Lys500
ZBTB33-5071R Recombinant Rhesus Macaque ZBTB33 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
ZBTB33-5071R-B Recombinant Rhesus Macaque ZBTB33 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ZBTB33-6851HF Recombinant Full Length Human ZBTB33 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 673 amino acids

    Involved Pathway

    ZBTB33 involved in several pathways and played different roles in them. We selected most pathways ZBTB33 participated on our site, such as Wnt Signaling Pathway and Pluripotency, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt Signaling Pathway and Pluripotency PPM1J,LRRK2,FOXD3,FBXW2

    Protein Function

    ZBTB33 has several biochemical functions, for example, metal ion binding,methyl-CpG binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB33 itself. We selected most functions ZBTB33 had, and list some proteins which have the same functions with ZBTB33. You can find most of the proteins on our site.

    Function Related Protein
    sequence-specific DNA binding TFCP2L1,SALL1A,CDX1B,FOXD1,RORAB,NR1H5,NFIL3-2,PRDM16,MSXC,DLX3
    protein binding RPL10,APITD1,POLE4,PIK3CA,DDX31,SH3GL3,UBE2W,LOC780933,CAP2,FAM117B
    metal ion binding ZNF354A,ADI1,CHPF,TGM2B,MICAL2,PAPD4,MOB4,NDUFS2,AMY1B,TKT
    methyl-CpG binding LRWD1,ZBTB4,MBD3A,MBD1B,MBD3B,UHRF1,MBD3,MBD3L1,MECP2,ZNF295

    Interacting Protein

    ZBTB33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB33 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB33.

    CTNND1;WDR48;q81sn0_bacan;AIM2;SF3B1;FOXM1;TRIML2;RNF169;TRMT10A;CCDC101;CLPTM1L;DPH7;KLF16;CCDC61

    Resources

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