YAF2
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Official Full Name
YY1 associated factor 2 -
Overview
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
YAF2;YY1 associated factor 2;YY1-associated factor 2;MGC41856
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
YAF2 involved in several pathways and played different roles in them. We selected most pathways YAF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with YAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
YAF2 has several biochemical functions, for example, protein binding,transcription coactivator activity,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by YAF2 itself. We selected most functions YAF2 had, and list some proteins which have the same functions with YAF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF295,DNAJB1,BICD1,Fgf15,BYSL,PRC1,UBTD1,TRDN,UBL4A,KCNIP2 |
| transcription corepressor activity | KCNIP3,ATF5,TBL1XR1A,CTCF,HIRA,SIRT1,HIPK2,SKI,ALX1,PRMT5 |
| transcription coactivator activity | TAF10,ZSCAN1,MED12,JUNB,BIRC2,TAF9,NACA,TAF11,PCBD1,CDK7 |
| zinc ion binding | DNAJC24,BHMT,TRIM55A,CCNB1IP1,PCGF2,NR6A1B,MGRN1A,RNF150A,ADAT3,SEC24A |
Interacting Protein
YAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of YAF2.
RING1;XAGE1A;SETBP1;YY1;q7ard3_yerpe;asnB;chbG;Ring1;MYC;CSNK2A2;BMI1;PCGF2
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References
- Vega, MI; Huerta-Yepez, S; et al. Rituximab-Mediated Cell Signaling and Chemo/Immuno-sensitization of Drug-Resistant B-NHL Is Independent of Its Fc Functions. CLINICAL CANCER RESEARCH 15:6582-6594(2009).
- de Nigris, F; Rossiello, R; et al. Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. CANCER RESEARCH 68:1797-1808(2008).
