XRN2
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Official Full Name
5-3 exoribonuclease 2 -
Overview
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. -
Synonyms
XRN2;5-3 exoribonuclease 2;DHP protein;Dhm1-like protein (mouse homolog)
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XRN2-265Z | Recombinant Zebrafish XRN2 | Mammalian Cells | Zebrafish | His |
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| XRN2-2713C | Recombinant Chicken XRN2 | Mammalian Cells | Chicken | His |
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| XRN2-219H | Recombinant Human XRN2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| XRN2-2372H | Recombinant Human XRN2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| XRN2-2372H-B | Recombinant Human XRN2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| XRN2-465HFL | Recombinant Full Length Human XRN2 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| Xrn2-7025M | Recombinant Mouse Xrn2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
XRN2 involved in several pathways and played different roles in them. We selected most pathways XRN2 participated on our site, such as Ribosome biogenesis in eukaryotes,RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | EXOSC8,CNOT4,PABPC5,PABPC1,EXOSC2,LSM8,ENO3,DCP1A,DHX36,CNOT3B |
| Ribosome biogenesis in eukaryotes | RBM28,ACK2,GNL3L,RIOK2,RNASEN,WDR43,POP7,GAR1,POP5,MPHOSPH10 |
Protein Function
XRN2 has several biochemical functions, for example, 5-3 exonuclease activity,5-3 exoribonuclease activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRN2 itself. We selected most functions XRN2 had, and list some proteins which have the same functions with XRN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 5-3 exonuclease activity | CPSF3,DXO,DCLRE1C,EXO1,FAN1,FEN1,DOM3Z,POLN |
| transcription termination site sequence-specific DNA binding | SETX |
| 5-3 exoribonuclease activity | DOM3Z |
| poly(A) RNA binding | G3BP1,C7orf50,KRR1,PA2G4,RPS19BP1,GNL3L,LUC7L3,RPS17L,HIST1H4H,RPS6 |
| zinc ion binding | ABP1,ISL1,ZCCHC6,TRIM7,NANOS1,PRICKLE1A,ING5,ZNF330,PIAS4B,TRIM35-22 |
Interacting Protein
XRN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRN2.
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