XPOT
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Official Full Name
exportin, tRNA (nuclear export receptor for tRNAs) -
Overview
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. -
Synonyms
XPOT;exportin, tRNA (nuclear export receptor for tRNAs);exportin-T;XPO3;AI452076;C79645;1110004L07Rik;3110065H13Rik;Exportin tRNA;tRNA exportin;exportin(tRNA)
Recombinant Proteins
- Zebrafish
- Chicken
- Rhesus macaque
- Human
- Rat
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XPOT-3974Z | Recombinant Zebrafish XPOT | Mammalian Cell | Zebrafish | His |
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| XPOT-4418C | Recombinant Chicken XPOT | Mammalian Cell | Chicken | His |
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| XPOT-5232R | Recombinant Rhesus monkey XPOT Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| XPOT-1939HCL | Recombinant Human XPOT cell lysate | Human | Non |
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| XPOT-5045R | Recombinant Rhesus Macaque XPOT Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| XPOT-5045R-B | Recombinant Rhesus Macaque XPOT Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Xpot-595R | Recombinant Rat Xpot Protein, His-tagged | E.coli | Rat | His | Met1-Lys269 |
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Involved Pathway
XPOT involved in several pathways and played different roles in them. We selected most pathways XPOT participated on our site, such as Gene Expression,RNA transport,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPOT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | NFIC,GTF3C4,ZNF454,TAF1A,NR2E3,SLC38A8,ELAVL1,PIWIL4,PTRF,ZNF223 |
| RNA transport | NUPL1,EIF2B1,NCBP1,EIF1B,AAAS,PEAK1,PHAX,EIF4A3,DDX39B,GEMIN7 |
| tRNA processing | LCMT2,MANEA,TSEN54,TYW1,OSGEP,TRMT1,POP1,QTRTD1,ADAT3,C22orf28 |
| tRNA processing in the nucleus | TSEN15,ELAC2,RPP14,POP7,C22orf28,POP4,TSEN34,C2orf49,C14orf166,TSEN54 |
Protein Function
XPOT has several biochemical functions, for example, Ran GTPase binding,nucleobase-containing compound transmembrane transporter activity,tRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPOT itself. We selected most functions XPOT had, and list some proteins which have the same functions with XPOT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | THG1L,AARSD1,RPL35A,IFIT5,CARS,CTU1,RARS,SEPSECS,TRMT1,PTCD1 |
| Ran GTPase binding | IPO4,TNPO1,IPO7,XPO1,RANBP1,XPO6,NUP153,DPY19L2,XPO7,RANGRF |
Interacting Protein
XPOT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPOT here. Most of them are supplied by our site. Hope this information will be useful for your research of XPOT.
TNFRSF1A;TNFRSF1B;CLN3;CAMKK2;MAP3K3;Dnaaf5;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;15-deoxy-delta(12,14;EGFR;MYC;XRCC1;RAN;IQCB1;Hsph1;ARMC6;P
Resources
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References
- Khacho, M; Mekhail, K; et al. eEF1A Is a Novel Component of the Mammalian Nuclear Protein Export Machinery. MOLECULAR BIOLOGY OF THE CELL 19:5296-5308(2008).
- Bohnsack, MT; Czaplinski, K; et al. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA-A PUBLICATION OF THE RNA SOCIETY 10:185-191(2004).
- Arts, GJ; Kuersten, S; et al. The role of exportin-t in selective nuclear export of mature tRNAs. EMBO JOURNAL 17:7430-7441(1998).
