WRB
-
Official Full Name
tryptophan rich basic protein -
Overview
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
WRB;tryptophan rich basic protein;tryptophan-rich protein;CHD5;Congenital heart disease 5 gene;Congenital heart disease 5 protein;FLJ51808;Tryptophan rich protein, congenital heart disease 5 protein;OTTHUMP00000069044;OTTHUMP00000069046;OTTHUMP00000109172;OTTHUMP00000165173
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Zebrafish
- Human
- Bovine
- zebrafish
- Mus musculus
- Pongo Abelii
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
WRB involved in several pathways and played different roles in them. We selected most pathways WRB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
WRB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by WRB itself. We selected most functions WRB had, and list some proteins which have the same functions with WRB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
WRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WRB here. Most of them are supplied by our site. Hope this information will be useful for your research of WRB.
Resources
Related Services
Related Products
References
- Young, MT; Beckmann, R; et al. Red-cell glycophorin A-band 3 interactions associated with the movement of band 3 to the cell surface. BIOCHEMICAL JOURNAL 350:53-60(2000).
- Poole, J; Banks, J; et al. Glycophorin A mutation Ala65 -> Pro gives rise to a novel pair of MNS alleles ENEP (MNS39) and HAG (MNS41) and altered Wr(b) expression: direct evidence for GPA band 3 interaction necessary for normal Wr(b) expression. TRANSFUSION MEDICINE 9:167-174(1999).
