WNK1
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Official Full Name
WNK lysine deficient protein kinase 1 -
Overview
The WNK [with no lysine (K)] family of serine/threonine kinases is characterized by having a cysteine in place of lysine in subdomain II of its kinase activation domain. The lysine necessary for phosphoryl transfer is located in an atypical position in th -
Synonyms
WNK1;WNK lysine deficient protein kinase 1;hereditary sensory neuropathy, type II , HSN2, PRKWNK1, protein kinase, lysine deficient 1;serine/threonine-protein kinase WNK1;HSAN2;erythrocyte 65 kDa protein;protein kinase with no lysine 1;prostate-de
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Flag
- Non
- His&Fc&Avi
Involved Pathway
WNK1 involved in several pathways and played different roles in them. We selected most pathways WNK1 participated on our site, such as EGFR1 Signaling Pathway,Ion channel transport,Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | STXBP1A,CEBPA,ZNF259,JUND,RALBP1,GRB14,MTA2,TNIP1,EPPK1,SPRY2 |
| Transmembrane transport of small molecules | SLC6A6A,ABCC2,TTYH3B,SLC34A2A,CCC2,SLC5A3A,SLC39A6,SLC29A1A,ATP2C1,TRPC4AP |
| Stimuli-sensing channels | CLCN5,ANO6,CLCN2,BEST1,SLC9B2,ANO10,CLCNKA,SLC9A10,TRPM1B,BSND |
| Ion channel transport | ASPH,TTYH2,SCNN1D,GLRBA,UNC79,TRPM4C,ATP13A,GABRR2A,FXYD6,CCC2 |
Protein Function
WNK1 has several biochemical functions, for example, ATP binding,chloride channel inhibitor activity,phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNK1 itself. We selected most functions WNK1 had, and list some proteins which have the same functions with WNK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SULT1A1,RAB11B,HDAC2,VIM,FAM65B,TPM1,SPARC,SNX3,PRH2,PRPSAP1 |
| protein serine/threonine kinase activity | CDC42BPB,RPS6KA1,MAPK14,PRKCZ,Aatk,ULK1A,RAF1,RIPK3,DAPK1,ROCK2B |
| protein kinase inhibitor activity | SOCS3A,CAMK2N1A,GMFB,SH3BP5B,JIP1,NCK1,SOCS6B,CHP,DUSP19,SOCS3B |
| chloride channel inhibitor activity | VAMP8,VTI1B,STX8,STX1A,STX7,CFTR |
| phosphatase binding | PPP1R36,MAPK1,CTSC,CARHSP1,TPRN,DLG1,ELFN1,SH3RF2,PPP1R18,SLC9A3R2 |
| ATP binding | CLK2B,ADCY8,SBK1,NLRP12,HIPK4,MAPK10,VRK1,ULK2,SLC27A5,KCNJ10 |
Interacting Protein
WNK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNK1.
PPP1CA;Syt2;OXSR1;ME2;ZNF839;q81y32_bacan;EPB41L2;TULP3;ARAF;PVR;TNFAIP3;SSFA2;HIVEP2;MYH9;ATXN1;YWHAG;YWHAE
Resources
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References
- Sato, A; Shibuya, H; et al. WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression. PLOS ONE 8:-(2013).
- Wade, JB; Fang, L; et al. Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F1385-F1393(2011).
