WIPI1

  • Official Full Name

    WD repeat domain, phosphoinositide interacting 1

  • Overview

    WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of;multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein;interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller;structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 (PubMed;15602573)).

  • Synonyms

    WIPI1;WD repeat domain, phosphoinositide interacting 1;WD repeat domain phosphoinositide-interacting protein 1;Atg18;ATG18A;FLJ10055;WIPI49;ATG 18;Atg18 protein homolog;WD repeat domain phosphoinositide interacting 1;WD repeat domain phosphoinositide interacting protein 1;WD40 repeat protein interacting with phosphoinositides of 49 kDa;WD40 repeat protein interacting with phosphoInositides of 49kDa;WIPI 1 alpha;WIPI 1;WIPI 49;WIPI 49 kDa;WIPI-1;WIPI1_HUMAN;WIPI-1 alpha
Cat.# Product name Source (Host) Species Tag Protein Length Price
WIPI1-3733H Recombinant Human WIPI1, GST-tagged E.coli Human GST 346-446aa
WIPI1-10706Z Recombinant Zebrafish WIPI1 Mammalian Cell Zebrafish His
WIPI1-310HCL Recombinant Human WIPI1 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    WIPI1 involved in several pathways and played different roles in them. We selected most pathways WIPI1 participated on our site, such as Cellular responses to stress,IRE1alpha activates chaperones,Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress RBBP4,HSPA12B,RBBP7,DYNLL2B,Txn1,AMBRA1A,POT1A,TXNRD2,CBX8,SUZ12A
    Unfolded Protein Response (UPR) KDELR3,SERP1,YIF1A,KLHDC3,DNAJB9,FKBP14,CTDSP2,HYOU1,C19orf10,DDX11
    Metabolism of proteins LTF,SPON1,CTSH,NAPG,SPON1B,RING1,ADAMTSL4,DPP4,PFDN5,GPR116
    Macroautophagy LC3,ATG4A,WDR45,GABARAP,AMBRA1A,RB1CC1,WIPI2,MAP1LC3B,AMBRA1B,ULK1A
    XBP1(S) activates chaperone genes SEC63,C19orf10,FKBP14,ASNA1,HYOU1,CTDSP2,SERP1,HDGF,KLHDC3,DNAJB9
    IRE1alpha activates chaperones HYOU1,C19orf10,TPP1,PREB,ADD1,KDELR3,DDX11,PDIA6,DNAJB9,FKBP14

    Protein Function

    WIPI1 has several biochemical functions, for example, androgen receptor binding,estrogen receptor binding,phosphatidylinositol-3,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIPI1 itself. We selected most functions WIPI1 had, and list some proteins which have the same functions with WIPI1. You can find most of the proteins on our site.

    Function Related Protein
    phosphatidylinositol-3-phosphate binding SESTD1,WDR45B,D6WSU116E,WDR45L,VPS36,LANCL2,SNX27,KIF16B,ZFYVE28,SNX20
    phosphatidylinositol-3,5-bisphosphate binding JPH2,RAG2,PHLDA3,MAPKAP1,KIF16B,CLVS1,WDR45,FAM21C,SESTD1,WDR45L
    androgen receptor binding PKN1,TRIM68,NCOA3,FOXH1,KAT5,PIAS2,BRCA1,PARK7,DDX5,TGFB1I1
    estrogen receptor binding XBP1,HSD17B10,STRN,MED1,PRMT2,PHB2,PPID,CCDC62,TMEM38A,PPARG
    receptor binding NSG1,TNFSF13B,PAOX,STRAP,FRK,AKAP9,PEX14,FGF1A,NTF7,PLG

    Interacting Protein

    WIPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WIPI1.

    pi3p;LGALS7B;PKP1;ATG2A;PPA1;KCTD15;BECN1;ATG12

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