WFIKKN1

  • Official Full Name

    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1

  • Overview

    This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.

  • Synonyms

    WFIKKN1;WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1;C16orf12, chromosome 16 open reading frame 12;WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1;RJD2;WFIKKN;C16orf12;Chromosome 16 open reading frame 12;GASP 2;GASP2;Growth and differentiation factor-associated serum protein;hGASP 2;WAP, follistatin/kazal, immunoglobulin, kunitz and netrin;WAP, FS, Ig, KU, and NTR containing protein;GASP-2;hGASP-2;OTTHUMP00000115417;WAP, FS, Ig, KU, and NTR-containing protein;growth and differentiation factor-associated serum protein 2;WAP, follistatin, immunoglobulin, kunitz and

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Rat
  • Human
  • Mammalian Cell
  • E. coli
  • HEK293
  • His
  • His&Fc&Avi

    Involved Pathway

    WFIKKN1 involved in several pathways and played different roles in them. We selected most pathways WFIKKN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WFIKKN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    WFIKKN1 has several biochemical functions, for example, enzyme inhibitor activity,metalloendopeptidase inhibitor activity,peptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WFIKKN1 itself. We selected most functions WFIKKN1 had, and list some proteins which have the same functions with WFIKKN1. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase inhibitor activity RECK,SERPINE1,PEBP1,MUG1,COL28A1,SERPINA10A,AGT,ITIH5,WFIKKN2,SERPINC1
    protein binding UPK3A,DAXX,GRB10,PIFO,P2RY6,NCAPH,DIEXF,PPIB,RUNX2,PPP3R1
    metalloendopeptidase inhibitor activity TIMP3,WFIKKN2,RECK,TIMP4,TIMP2B,LXN,FETUB,TIMP2A,COL4A3,SPOCK3
    enzyme inhibitor activity APOV1,TXNIP,UGT1A1,OAZ2B,PDE6H,UGT1A9,PRPSAP1,HSPBP1,APBA3,CD46
    peptidase inhibitor activity WFDC6B,WFDC13,SPINK6,COL7A1,PI15,PI15A,Serpina1c,WFDC15B,MUG2,WFDC15A

    Interacting Protein

    WFIKKN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFIKKN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFIKKN1.

    Resources

    Research Area

    Serine Proteases and Regulators

    References

    • Harris, RA; Tardif, SD; et al. Evolutionary genetics and implications of small size and twinning in callitrichine primates. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:1467-1472(2014).
    • Szlama, G; Trexler, M; et al. Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. FEBS JOURNAL 280:3822-3839(2013).

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