WFDC2
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Official Full Name
WAP four-disulfide core domain 2 -
Overview
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008] -
Synonyms
WFDC2;WAP four-disulfide core domain 2;HE4;WAP5;EDDM4;dJ461P17.6;WAP four-disulfide core domain protein 2;epididymal protein 4;epididymal secretory protein E4;putative protease inhibitor WAP5;WAP domain containing protein HE4-V4;major epididymis-specific protein E4;epididymis-specific, whey-acidic protein type, four-disulfide core
Recombinant Proteins
- Human
- Rat
- Mouse
- Canine
- E.coli
- HEK293
- Yeast
- Mammalian Cell
- Human Cell
- Mouse
- Mammalian cells
- HEK293T
- GST
- His
- His&Avi
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
- Flag
- Fc
Involved Pathway
WFDC2 involved in several pathways and played different roles in them. We selected most pathways WFDC2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WFDC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
WFDC2 has several biochemical functions, for example, aspartic-type endopeptidase inhibitor activity,cysteine-type endopeptidase inhibitor activity,endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WFDC2 itself. We selected most functions WFDC2 had, and list some proteins which have the same functions with WFDC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | AMBP,MUG2,SERPINB1L4,SERPINA6,SERPINA1A,SPINK11,WFDC8,TFPI,SPINT4,WFDC1 |
| endopeptidase inhibitor activity | C3A.6,PI3,SPINK2,UCHL5,RENBP,SERPINA1E,A1i3,PZP,Hc,C3A.2 |
| cysteine-type endopeptidase inhibitor activity | CST8,CST14B.1,CST6,AHSG2,CTLA2B,NGP,SERPINB3,BIRC5A,CST11,BIRC5 |
Interacting Protein
WFDC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFDC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFDC2.
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