WDR79
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Official Full Name
WRAP53 WD repeat containing, antisense to TP53 -
Overview
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. -
Synonyms
TCAB1;WDR79;FLJ10385;telomerase Cajal body protein 1;OTTHUMP00000166046;OTTHUMP00000166047;OTTHUMP00000233829;OTTHUMP00000233830;OTTHUMP00000233831;WD repeat domain 79;WD40 protein Wrap53;WD repeat-containing protein 79;WD40 repeat-containing protein encoding RNA antisense to p53
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Involved Pathway
WDR79 involved in several pathways and played different roles in them. We selected most pathways WDR79 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR79 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
WDR79 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by WDR79 itself. We selected most functions WDR79 had, and list some proteins which have the same functions with WDR79. You can find most of the proteins on our site.
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Interacting Protein
WDR79 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR79 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR79.
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References
- Henriksson, S; Rassoolzadeh, H; et al. The scaffold protein WRAP53 beta orchestrates the ubiquitin response critical for DNA double-strand break repair. GENES & DEVELOPMENT 28:2726-2738(2014).
- Bonab, AS; Pouladi, N; et al. Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population. MEDICAL ONCOLOGY 31:-(2014).
