WBSCR22
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Official Full Name
Williams Beuren syndrome chromosome region 22 -
Overview
This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found. -
Synonyms
WBSCR22;Williams Beuren syndrome chromosome region 22;uncharacterized methyltransferase WBSCR22;MGC2022;MGC5140;MGC19709;PP3381;WBMT;HASJ4442;HUSSY 3;HUSSY3;WBS22_HUMAN;Williams Beuren candidate region putative methyltransferase;Williams Beuren syndrome chromosome region 22 protein;Williams-Beuren syndrome chromosomal region 22 protein;Williams-Beuren candidate region putative methyltransferase;HUSSY-3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WBSCR22-3385C | Recombinant Chicken WBSCR22 | Mammalian Cell | Chicken | His |
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| WBSCR22-5191R | Recombinant Rhesus monkey WBSCR22 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| WBSCR22-5264Z | Recombinant Zebrafish WBSCR22 | Mammalian Cell | Zebrafish | His |
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| WBSCR22-362HCL | Recombinant Human WBSCR22 293 Cell Lysate | HEK293 | Human | Non |
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| WBSCR22-5004R | Recombinant Rhesus Macaque WBSCR22 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| WBSCR22-5004R-B | Recombinant Rhesus Macaque WBSCR22 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
WBSCR22 involved in several pathways and played different roles in them. We selected most pathways WBSCR22 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WBSCR22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
WBSCR22 has several biochemical functions, for example, methyltransferase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WBSCR22 itself. We selected most functions WBSCR22 had, and list some proteins which have the same functions with WBSCR22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methyltransferase activity | MLL5,Mettl11b,PRMT3,FTSJD2,PRDM1,METTL5,METTL25,TRMT10C,NSUN5,DNMT4 |
| poly(A) RNA binding | NONO,ZFP326,MAZ,LSM6,PTCD1,IMMT,ZCCHC7,SEC63,DZIP3,EXOSC6 |
Interacting Protein
WBSCR22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WBSCR22 here. Most of them are supplied by our site. Hope this information will be useful for your research of WBSCR22.
FOS;PRKAB1;OAS1;VCP;PKN1;gltX;ssrna_ag;NPM1;Rpl35
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References
- Verges, L; Molina, O; et al. Deletions and duplications of the 22q11.2 region in spermatozoa from DiGeorge/velocardiofacial fathers. MOLECULAR CYTOGENETICS 7:-(2014).
- Gimelli, S; Chrast, J; et al. A t(7;12) Balanced Translocation With Breakpoints Overlapping Those of the Williams-Beuren and 12q14 Microdeletion Syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 152A:1285-1294(2010).
