WASL

  • Official Full Name

    Wiskott-Aldrich syndrome-like

  • Overview

    This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

  • Synonyms

    WASL;Wiskott-Aldrich syndrome-like;NWASP;N-WASP;neural Wiskott-Aldrich syndrome protein

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Mouse
  • E.coli
  • Wheat Germ
  • HEK293
  • Mammalian Cell
  • In Vitro Cell Free System
  • HEK293T
  • Mamanlian cells
  • His
  • GST
  • Myc&DDK
  • Non
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
WASL-3699H Recombinant Human WASL, His-tagged E.coli Human His 1-350aa
WASL-320H Recombinant Human WASL, GST-tagged Wheat Germ Human GST
WASL-321H Recombinant Human WASL, MYC/DDK-tagged HEK293 Human Myc&DDK
WASL-4346C Recombinant Chicken WASL Mammalian Cell Chicken His
WASL-5185R Recombinant Rhesus monkey WASL Protein, His-tagged Mammalian Cell Rhesus macaque His
WASL-367HCL Recombinant Human WASL 293 Cell Lysate HEK293 Human Non
WASL-4998R Recombinant Rhesus Macaque WASL Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
WASL-4998R-B Recombinant Rhesus Macaque WASL Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
WASL-547HF Recombinant Full Length Human WASL Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 505 amino acids
Wasl-6966M Recombinant Mouse Wasl Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
WASL-8985HFL Recombinant Full Length Human WASL, Flag-tagged Mamanlian cells Human Flag Full L.

    Involved Pathway

    WASL involved in several pathways and played different roles in them. We selected most pathways WASL participated on our site, such as Chemokine signaling pathway,Endocytosis,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with WASL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bacterial invasion of epithelial cells ARPC5,CD2AP,WASF2,VCL,CTNNA2,SEPT12,SEPT2,CAV3,PTK2,CRKL
    Pathogenic Escherichia coli infection CD14,TUBA1A,ABL1,EZR,ARPC5L,HCLS1,TUBAL3,NCK1,NCL,TUBB
    Adherens junction PTPN6,PTPRM,TJP1,PVRL3,PTPRFB,CTNNA1,YES1,FYNA,BAIAP2A,WASLB
    Regulation of Actin Cytoskeleton ARPC5B,PIP5K1C,RRAS2,SSH2,CD14,ITGAV,DIAP3,RAC1A,FGD,INSRR
    Choline metabolism in cancer EIF4EBP1,PDGFRB,PDGFRA,GPCPD1,PPAP2C,PIP5K1B,PPAP2B,HIF1A,RHEB,GRB2
    Endocytosis ARRB2A,CHMP3,RAB22A,PSD2,HSPA6,WASH,WIPF1A,MVB12A,VPS29,CXCR4A
    Fc gamma R-mediated phagocytosis PPAP2C,PIP5K1A,MYO10,WASF2,PIK3CB,ARPC5L,PIK3CG,PIK3R2,BIN1,RAF1
    Shigellosis ITGB1,PFN1,ATG5,MAPK11,MAD2L2,NFKBIA,IL-8,ROCK1,WAS,RIPK2
    Salmonella infection ARPC5L,TLR5,FLNB,WASB,FLNA,ARPC5LA,ACTB,CXCL8B.3,CD14,IL6

    Protein Function

    WASL has several biochemical functions, for example, GTPase regulator activity,actin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WASL itself. We selected most functions WASL had, and list some proteins which have the same functions with WASL. You can find most of the proteins on our site.

    Function Related Protein
    GTPase regulator activity RIMS1,RALGDS,GPSM1B,DNAJA3,GPSM2,GPSM3,PCP2,TSC1,ARL2BP,RGS14A
    protein binding AUP1,MAP4K3,DIP2A,DNAJC27,VEPH1,PIP,S100A1,USP42,CD247,C1orf50
    actin binding PALLD,MYH1,SNTA1,LSP1,GSNB,GMFG,UPF3B,SHROOM1,MED28,GCET2

    Interacting Protein

    WASL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WASL here. Most of them are supplied by our site. Hope this information will be useful for your research of WASL.

    WIPF1;GRB2;CDC42;ACTR3

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