VNN2
-
Official Full Name
vanin 2 -
Overview
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
VNN2;vanin 2;vascular non-inflammatory molecule 2;FOAP 4;GPI 80;pantetheinase;FOAP-4;Glycosylphosphatidyl inositol-anchored protein GPI-80;GPI-80;OTTHUMP00000017228;OTTHUMP00000233789;OTTHUMP00000233791;Protein FOAP-4;Vanin-2;Vannin 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| VNN2-3232H | Recombinant Human VNN2 protein(Met1-Ser492), His-tagged | HEK293 | Human | His | Met1-Ser492 | |
| VNN2-2268HCL | Recombinant Human VNN2 cell lysate | Human Cell | Human | Non |
|
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| VNN2-01H | Active Recombinant Human VNN2 Protein, Fc-tagged, Biotinylated | Human cells | Human | Fc | 23-492 |
|
| VNN2-06H | Active Recombinant Human VNN2 Protein (Extracellular Domain, Gln23-Ser492), C-Fc-tagged | Human cells | Human | Fc | Gln23-Ser492 |
|
| VNN2-573H | Recombinant Human VNN2 Protein, His-tagged | E.coli | Human | His | Gln23-Pro329 |
|
Involved Pathway
VNN2 involved in several pathways and played different roles in them. We selected most pathways VNN2 participated on our site, such as Pantothenate and CoA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VNN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pantothenate and CoA biosynthesis | PANK4,DPYDB,PANK1B,VNN1,PANK1,PANK2,ENPP3,PPCDC,DPYS,ENPP1 |
Protein Function
VNN2 has several biochemical functions, for example, pantetheine hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VNN2 itself. We selected most functions VNN2 had, and list some proteins which have the same functions with VNN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pantetheine hydrolase activity | VNN1,VNN3 |
Interacting Protein
VNN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VNN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VNN2.
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