VDAC3
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Official Full Name
voltage-dependent anion channel 3 -
Overview
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are;small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small;metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in;translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition;pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript;variants encoding different isoforms have been described for this gene. -
Synonyms
VDAC3;voltage-dependent anion channel 3;voltage-dependent anion-selective channel protein 3;hVDAC3;mVDAC3;Outer mitochondrial membrane protein porin 3;voltage dependent anion channel 3;VDAC-3;voltage-dependent anion channel 5, pseudogene;voltage-dependent anion channel 1 pseudogene 5;VDAC5P;VDAC1P5
Recombinant Proteins
- Human
- Zebrafish
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- His&GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| VDAC3-3182H | Recombinant Human VDAC3 protein, His-tagged | E.coli | Human | His | 1-283 aa | |
| VDAC3-12447Z | Recombinant Zebrafish VDAC3 | Mammalian Cells | Zebrafish | His |
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| VDAC3-155H | Recombinant Human VDAC3 Protein, GST/His-tagged | E.coli | Human | His&GST |
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| VDAC3-6512R | Recombinant Rat VDAC3 Protein | Mammalian Cells | Rat | His |
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| VDAC3-965H | Recombinant Human VDAC3 | Mammalian Cells | Human | His |
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| VDAC3-417HCL | Recombinant Human VDAC3 293 Cell Lysate | HEK293 | Human | Non |
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| VDAC3-4286H | Recombinant Human VDAC3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| VDAC3-4286H-B | Recombinant Human VDAC3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| VDAC3-6168R | Recombinant Rat VDAC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| VDAC3-6168R-B | Recombinant Rat VDAC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
VDAC3 involved in several pathways and played different roles in them. We selected most pathways VDAC3 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | AVPR1A,AKR1C1,DRD1B,CACNA1B,PLCG2,TNNC2,PHKA1,DRD1A,RYR1B,PPP3CA |
| Huntingtons disease | COX7A2,GRIN1,NDUFV1,UQCRH,NDUFA12,SP1,DNAI2,DNAH5,ATP5G3,POLR2F |
| cGMP-PKG signaling pathway | ATP1A3,CREB3L2,VDAC2,IRS1,KCNJ8,PPP1CC,NFATC2,CALM2,SLC8A2,MYLK4 |
| Parkinsons disease | NDUFB4,TH,COX5A,ATP5G1,NDUFAB1,NDUFS6,ATP5E,GPR37,NDUFA13,Atp5g2 |
| Hepatitis B | IL6,IFNA12,MAVS,Fasl,PRKCA,CREB3L3,CREB3L2,PIK3R5,CREB5,BCL2 |
| Viral carcinogenesis | CREB3L3,RANBP1,PIK3R1,TRAF3,HIST1H4N,PIK3CD,GTF2H2,HIST2H4,HDAC7A,MRPS18B |
| HTLV-I infection | SMAD4,FZD5,CD40,HRAS,RB1,XBP1,DVL2,TBPL1,H2-AA,GPS2 |
Protein Function
VDAC3 has several biochemical functions, for example, nucleotide binding,porin activity,voltage-gated anion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC3 itself. We selected most functions VDAC3 had, and list some proteins which have the same functions with VDAC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| porin activity | VDAC1,TOMM40,VDAC2,TOMM40L,AQP9 |
| voltage-gated anion channel activity | SLC17A3,VDAC2,VDAC1,GPR89 |
| nucleotide binding | MAPK12B,GNA11B,RALAB,GMPPAA,UCK2A,PRAC,SRSF7A,PKM,PRKCHB,UMPS |
Interacting Protein
VDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC3.
env;HLA-B;MAGEA6;CASP4;ACTB;Tubb4b;DHRS2;SERINC3;IKBKE;GSTK1;DDX24;ATF2;HTT;ICT1;Rmdn3;SLC38A1;ACAD9
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References
- Narendra, DP; Kane, LA; et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. AUTOPHAGY 6:1090-1106(2010).
- Messina, A; Reina, S; et al. Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique. MOLECULAR BIOSYSTEMS 10:2134-2145(2014).
