USF2
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Official Full Name
upstream transcription factor 2, c-fos interacting -
Overview
The ubiquitously expressed cellular upstream stimulatory factor (USF) consists of 43kDa (USF-1) and 44kDa (USF-2) polypeptides which independently exhibit site-specific DNA binding and are members of the c-Myc-related family of regulatory factors containing helix-loop-helix domains. USF also contains a leucine repeat that is required for efficient DNA binding. -
Synonyms
USF2;upstream transcription factor 2, c-fos interacting;upstream stimulatory factor 2;bHLHb12;FIP;FOS-interacting protein;c-fos interacting protein;major late transcription factor 2;class B basic helix-loop-helix protein 12
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| USF2-3689H | Recombinant Human USF2 protein, GST-tagged | E.coli | Human | GST | 1-346 aa | |
| USF2-17891M | Recombinant Mouse USF2 Protein | Mammalian Cell | Mouse | His |
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| USF2-6463R | Recombinant Rat USF2 Protein | Mammalian Cell | Rat | His |
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| USF2-6595Z | Recombinant Zebrafish USF2 | Mammalian Cell | Zebrafish | His |
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| USF2-478HCL | Recombinant Human USF2 293 Cell Lysate | HEK293 | Human | Non |
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| USF2-3285H | Recombinant Human USF2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| USF2-6119R | Recombinant Rat USF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| USF2-6119R-B | Recombinant Rat USF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Usf2-6860M | Recombinant Mouse Usf2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| USF2-9941M | Recombinant Mouse USF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| USF2-9941M-B | Recombinant Mouse USF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
USF2 involved in several pathways and played different roles in them. We selected most pathways USF2 participated on our site, such as Validated transcriptional targets of AP1 family members Fra1 and Fra2, which may be useful for your reference. Also, other proteins which involved in the same pathway with USF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated transcriptional targets of AP1 family members Fra1 and Fra2 | MGP,BGLAP,IVL,CXorf15 |
Protein Function
USF2 has several biochemical functions, for example, bHLH transcription factor binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USF2 itself. We selected most functions USF2 had, and list some proteins which have the same functions with USF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | MESPBA,TBX2A,SMAD2,ELF2,ZNF41,GTF2I,REL,HOXB5A,TEAD1,RXRA |
| protein binding | KCTD9,ROPN1,SIP1,TNFAIP8L2,EDA,PYGL,BCL2L12,TMED9,TRPC1,GPRC5A |
| protein homodimerization activity | SLC39A13,PRPS2,G6PDX,ADRB2,TFAP4,NAMPT,S100A1,ACVR1,SDS,CREB3L3 |
| protein heterodimerization activity | CAV2,CHUK,BMP6,HIST1H4B,AGTR1A,ADRA2A,PRMT8,BAD,H2-Q10,SNX6 |
| bHLH transcription factor binding | TCF3,SIRT1,LMO2,EP300,IKZF4,RUNX2,MAP3K10,TCF4,SOX9,USF1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SRF,PDX1,PROX1,NR5A2,CEBPB,SNAI2,GATA6,GLI1,RFX1,NKX2-5 |
| sequence-specific DNA binding | HNF1B,LHX5,HOXA11A,TBX1,HSF4,MKXA,HES1,FOXK2,EGR1,POUV |
Interacting Protein
USF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USF2.
USF1;TEAD2;FOS;LZTS2;rorg_human_ebox4_dna-probe;BIRC5;HSPA4L;IGHG2
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References
- Jiang, SL; Galindo, MR; et al. Purification and identification of a transcription factor, USF-2, binding to E-box element in the promoter of human telomerase reverse transcriptase (hTERT). PROTEOMICS 10:203-211(2010).
- van Deursen, D; Jansen, H; et al. Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. DIABETOLOGIA 51:2078-2087(2008).
