UROD
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Official Full Name
uroporphyrinogen decarboxylase -
Overview
Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.). Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis. -
Synonyms
UROD;uroporphyrinogen decarboxylase;uroporphyrinogen III decarboxylase;PCT;UPD
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Strep
- Myc&DDK
- His&GST
- His&Fc&Avi
Involved Pathway
UROD involved in several pathways and played different roles in them. We selected most pathways UROD participated on our site, such as Porphyrin and chlorophyll metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with UROD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | UCKL1,LPIN1,COQ3,MGAT1,UPRT,QDPRB2,PPAP2CB,AMDHD1,PCCA,GKUP |
| Porphyrin and chlorophyll metabolism | UGT2B7,UGT1A7,UGT2A3,FXN,FECH,UGT1A6,COX15,UGT1A6B,MMAB,HCCSA.1 |
Protein Function
UROD has several biochemical functions, for example, ferrous iron binding,protein binding,uroporphyrinogen decarboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UROD itself. We selected most functions UROD had, and list some proteins which have the same functions with UROD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ferrous iron binding | FECH,PLOD1,SERPINB1A,ALKBH2,ISCUB,FTO,TET2,SNCA,ALKBH1,FXN |
| protein binding | MTRR,SRGN,COBL,NOMO2,SYNJ2,GTF2A1,ATP4B,CADM1,CHIC2,USP28 |
Interacting Protein
UROD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UROD here. Most of them are supplied by our site. Hope this information will be useful for your research of UROD.
FAM84B;Urod;EGFR;VIM;pepQ;CHD3;HMGXB4;FAF1
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