UPF3B
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Official Full Name
UPF3 regulator of nonsense transcripts homolog B (yeast) -
Overview
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
UPF3B;UPF3 regulator of nonsense transcripts homolog B (yeast);MRX62;UPF3X;HUPF3B;MRXS14;RENT3B;regulator of nonsense transcripts 3B;hUpf3p-X;mental retardation, X-linked 62;nonsense mRNA reducing factor 3B;up-frameshift suppressor 3 homolog B;up-frameshift suppressor 3 homolog on chromosome X
Recombinant Proteins
- Zebrafish
- Human
- Rhesus macaque
- Mouse
- Mammalian Cell
- E.coli
- HEK293T
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UPF3B-11191Z | Recombinant Zebrafish UPF3B | Mammalian Cell | Zebrafish | His |
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| UPF3B-31673TH | Recombinant Human UPF3B, His-tagged | E.coli | Human | His | 277-470 a.a. |
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| UPF3B-5108R | Recombinant Rhesus monkey UPF3B Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| UPF3B-2483H | Recombinant Human UPF3B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| UPF3B-4921R | Recombinant Rhesus Macaque UPF3B Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| UPF3B-4921R-B | Recombinant Rhesus Macaque UPF3B Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| UPF3B-631H | Recombinant Human UPF3B Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Upf3b-6846M | Recombinant Mouse Upf3b Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
UPF3B involved in several pathways and played different roles in them. We selected most pathways UPF3B participated on our site, such as RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPF3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | CPSF7,PPP2R3C,PABPC1A,WIBG,CPSF2,DAZAP1,GSPT1,SMG6,MSI2B,RBM8A |
| RNA transport | STRAP,EIF1B,EIF3EB,NXF3,MAGOHB,EIF4EBP2,EIF3HB,NUP98,NCBP1,CYFIP2 |
Protein Function
UPF3B has several biochemical functions, for example, actin binding,calmodulin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPF3B itself. We selected most functions UPF3B had, and list some proteins which have the same functions with UPF3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | FGD4,MYBPC3,PHACTR4B,ABLIM1A,EPB41L2,PPP1R9B,DAG1,PARVAA,MICAL2,MYHZ1.1 |
| protein binding | COBRA1,RPP25,DKK1,AVPR1A,PLAA,LIMS3L,POP5,DDX42,NDEL1,SNX7 |
| calmodulin binding | SNTB2,KCNH1,SPHK1,MYH9,CNGA2,RIT2,CNN1,CNN3,TRPV6,MKNK1 |
Interacting Protein
UPF3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPF3B here. Most of them are supplied by our site. Hope this information will be useful for your research of UPF3B.
RBM8A;UPF2;EIF4A3
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References
- Tarpey, PS; Raymond, FL; et al. Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. NATURE GENETICS 39:1127-1133(2007).
