UPF3A
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Official Full Name
UPF3 regulator of nonsense transcripts homolog A -
Overview
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. -
Synonyms
UPF3A;UPF3 regulator of nonsense transcripts homolog A (yeast);regulator of nonsense transcripts 3A;HUPF3A;RENT3A;UPF3;hUpf3;nonsense mRNA reducing factor 3A;up-frameshift suppressor 3 homolog A;FLJ35267;FLJ57970
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UPF3A-31672TH | Recombinant Human UPF3A, His-tagged | E.coli | Human | His | 1-296 a.a. |
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| UPF3A-7973Z | Recombinant Zebrafish UPF3A | Mammalian Cell | Zebrafish | His |
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| UPF3A-1889HCL | Recombinant Human UPF3A cell lysate | Human | Non |
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| UPF3A-6102H | Recombinant Human UPF3A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Upf3a-6845M | Recombinant Mouse Upf3a Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
UPF3A involved in several pathways and played different roles in them. We selected most pathways UPF3A participated on our site, such as RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPF3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | RPP14,TRNT1,EIF1AXB,ELAC1,EIF4E1C,PABPC1A,RNPS1,RANBP2,EIF3J,SEC13 |
| mRNA surveillance pathway | BCL2L2-PABPN1,ETF1B,SMG6,EIF4A3,CPSF5,MAGOH,PABPC1L2A,CPSF7,PPP1CC,MAGOH2 |
Protein Function
UPF3A has several biochemical functions, for example, RNA binding,nucleocytoplasmic transporter activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPF3A itself. We selected most functions UPF3A had, and list some proteins which have the same functions with UPF3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | CNOT8,HNRPL,RPL38,TRDMT1,RBM39A,SUZ12,PAPOLG,HNRNPU,DKC1,PABPC1L |
| protein binding | RPTOR,CRY1,SMIM3,AKIP1,DOK1,DDX31,CIR1,HAT1,PER2,CHD1 |
| nucleotide binding | SNRKB,U2AF2A,ALYREF,RAB25B,U2AF1L4,PABPC1A,RBM5,SNRKA,RPS6KAL,HSPA4B |
| nucleocytoplasmic transporter activity | NUP107,RBM22,NUP214,NUP54,TPR,NUP35,NUPL1,NUP160,TPRB,NUP133 |
Interacting Protein
UPF3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPF3A here. Most of them are supplied by our site. Hope this information will be useful for your research of UPF3A.
RBM8A;UPF1;ALYREF;SMG1;NXF1;UPF2;GSK3B;IFITM2;fadE;PIGT;FGFR1OP
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