UNC45A
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Official Full Name
unc-45 homolog A (C. elegans) -
Overview
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90;(HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002;(PubMed 12356907); Chadli et al., 2006 (PubMed 16478993)). -
Synonyms
UNC45A;unc-45 homolog A (C. elegans);protein unc-45 homolog A;GC UNC45;SMAP 1;smooth muscle cell associated protein 1;AW538196;FLJ10043;GCUNC 45;GCUNC45;General cell UNC45;IRO039700;MGC125248;OTTMUSP00000030133;Protein unc45 homolog A;RGD1305357;SMAP1;Stromal membrane-associated protein 1;Unc-45A;Unc45 homolog A (C. elegans);smooth muscle cell associated protein-1;smooth muscle cell-associated protein 1;SMAP-1;GC-UNC45;GCUNC-45
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
UNC45A involved in several pathways and played different roles in them. We selected most pathways UNC45A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC45A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
UNC45A has several biochemical functions, for example, Hsp90 protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC45A itself. We selected most functions UNC45A had, and list some proteins which have the same functions with UNC45A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LEPR,SHPRH,VPS16,TCEB3,RELB,PIK3CD,TUBA3D,MAB21L1,KCP,SPRR1A |
| Hsp90 protein binding | HIF1A,USP19,HDAC6,FKBP6,ERN1,CHORDC1,STUB1,UNC45B,ARNTL,PACRG |
Interacting Protein
UNC45A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC45A here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC45A.
MEOX2;MAX;MAX;MARCH10;MID2;7242199;PTP4A3
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References
- Bernick, EP; Zhang, PJ; et al. Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos. BMC CELL BIOLOGY 11:-(2010).
- Wohlgemuth, SL; Crawford, BD; et al. The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. DEVELOPMENTAL BIOLOGY 303:483-492(2007).
