UCP2
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Official Full Name
uncoupling protein 2 (mitochondrial, proton carrier) -
Overview
UCP2 also known as mitochondrial uncoupling protein 2 is a 33 kD member of the mitochondrial anion carrier protein family. This protein is expressed in the mitochondria and is highly expressed in brain, kidney, liver, brown adipose tissue, heart, and musc -
Synonyms
UCP2;uncoupling protein 2 (mitochondrial, proton carrier);mitochondrial uncoupling protein 2;SLC25A8;UCP 2;solute carrier family 25 member 8;UCPH;BMIQ4
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Rat
- Zebrafish
- Pongo Abelii
- Cyprinus carpio
- zebrafish
- Dog
- Sus scrofa (Pig)
- Bovine
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
UCP2 involved in several pathways and played different roles in them. We selected most pathways UCP2 participated on our site, such as Electron Transport Chain,Energy Metabolism,FOXA2 and FOXA3 transcription factor networks, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| The citric acid (TCA) cycle and respiratory electron transport | COX16,NDUFAF7,BRP44,ADHFE1,PDK2,ETFB,PDK4,SCO1,SURF1,ETFA |
| The fatty acid cycling model | SLC25A14,SLC25A27,UCP3 |
| Metabolism | CTHL,PCBD1,AMD2,ARSE,FAM96B,ADSSL1,CIAO1,DCK,CD320,VAPB |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | C20orf7,UCP3,ETFA,ETFDH,COX11,ATP5S,ATP5L,ETFB,NDUFAF3,FAM36A |
| Energy Metabolism | UCP3,PPARGC1B,TFB2M,TFB1M,MYBBP1A,MEF2B,ESRRA,GABPA |
| Electron Transport Chain | COX6A2,UCP3,COX6B1,COX7C,SURF1,COX6A1,ATP5S,COX4I1,COX6C,COX7A2 |
| Mitochondrial Uncoupling Proteins | SLC25A14,SLC25A27,UCP3 |
| FOXA2 and FOXA3 transcription factor networks | CPT1C,TTR,KCNJ11,CPT1A,FOXF1,FOXA1,CPT1B,CEBPA,DLK1 |
Protein Function
UCP2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UCP2 itself. We selected most functions UCP2 had, and list some proteins which have the same functions with UCP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SLC9A1,RNF115,SNX12,HPS6,MATN3,DUT,SIRT3,MAP3K5,RFPL3,PRKCQ |
Interacting Protein
UCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCP2.
KRTAP10-7;pepP
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References
- Zhu, R; Rupprecht, A; et al. Mapping the Nucleotide Binding Site of Uncoupling Protein 1 Using Atomic Force Microscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135:3640-3646(2013).
- Kwok, KHH; Ho, PWL; et al. Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. FREE RADICAL BIOLOGY AND MEDICINE 49:1023-1035(2010).
