UBR5
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Official Full Name
ubiquitin protein ligase E3 component n-recognin 5 -
Overview
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. -
Synonyms
UBR5;ubiquitin protein ligase E3 component n-recognin 5;E3 ubiquitin protein ligase, HECT domain containing, 1 , EDD1;E3 ubiquitin-protein ligase UBR5;DD5;EDD;HYD;KIAA0896;hHYD;ubiquitin-protein ligase;progestin induced protein;progestin-induce
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UBR5-4053H | Recombinant Human UBR5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| UBR5-7576Z | Recombinant Zebrafish UBR5 | Mammalian Cell | Zebrafish | His |
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| UBR5-4054H | Recombinant Human UBR5 protein, His-tagged | E. coli | Human | His | 2450-2799 aa |
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Involved Pathway
UBR5 involved in several pathways and played different roles in them. We selected most pathways UBR5 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CDC26,UBE2S,TRIM32,CUL5,BIRC3,PIAS2,KLHL9,UBE2I,SMURF2,MAP3K1 |
Protein Function
UBR5 has several biochemical functions, for example, RNA binding,ligase activity,ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR5 itself. We selected most functions UBR5 had, and list some proteins which have the same functions with UBR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin binding | KIF18A,DYRK2,UBE2NB,OTUB1,NSFL1C,MARK4,C36E6.2,TNFAIP3,TRP53INP2,UBAP1 |
| RNA binding | IMPDH1,PUS10,CNBPA,LIN28A,OASL2,RPS4Y1,JAKMIP1,QKIA,RAVER1,RPS16 |
| ubiquitin protein ligase activity | C18orf25,UBE3C,PJA1,RNF181,UBE2KB,RNF14,HACE1,RNF144A,HERC3,AMFR |
| ubiquitin-protein transferase activity | ZFP91,RNF5,UBE2N,UBE2D2A,TRIM36,FBXO4,TRIM32,RNF31,BIRC5B,TNFAIP3 |
| ligase activity | NSMCE1,GLULB,RCHY1,RNF111,PET112L,UBE3B,UBE3A,TRIM37,SIAH1A,MGRN1 |
| zinc ion binding | QPCTLA,MARCH6,NR1H3,PGGT1B,EEA1,ZRANB1,ZGLP1,GCH1,ZADH2,RNF32 |
Interacting Protein
UBR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR5.
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References
- Wu, C; Chen, ZJ; et al. DUBA-UBR5 axis: other than transactivation. CELL RESEARCH 25:273-274(2015).
- Rutz, S; Kayagaki, N; et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. NATURE 518:-(2015).
