UBR4
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Official Full Name
ubiquitin protein ligase E3 component n-recognin 4 -
Overview
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. -
Synonyms
UBR4;ubiquitin protein ligase E3 component n-recognin 4;zinc finger, UBR1 type 1 , ZUBR1;E3 ubiquitin-protein ligase UBR4;KIAA0462;KIAA1307;RBAF600;600 kDa retinoblastoma protein associated factor;600 kDa retinoblastoma protein-associated factor;N-recognin-4;p600;Retinoblastoma associated factor 600 like protein;Retinoblastoma associated factor of 600 kDa;Retinoblastoma-associated factor 600;Retinoblastoma-associated factor of 600 kDa;Ubiquitin protein ligase E3 component n recognin 4;UBR4_HUMAN;Zinc finger UBR1 type protein 1;Zinc finger UBR1-type protein 1;Zinc finger, UBR1 type 1;ZUBR 1;ZUBR1;OTTHUMP00000002585;retinoblastoma-associated factor 600-like protein;RP5-1126H10.1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UBR4-3562H | Recombinant Human UBR4, His-tagged | E.coli | Human | His | C-term-349aa | |
| UBR4-32H | Recombinant Human UBR4 protein, His-tagged | E.coli | Human | His | Val124~Arg396 | |
| UBR4-33H | Recombinant Human UBR4 protein, GST-tagged | E.coli | Human | GST | 451-799 aa | |
| UBR4-17762M | Recombinant Mouse UBR4 Protein | Mammalian Cell | Mouse | His |
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| UBR4-01H | Recombinant Human UBR4 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| UBR4-9860M | Recombinant Mouse UBR4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| UBR4-9860M-B | Recombinant Mouse UBR4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
UBR4 involved in several pathways and played different roles in them. We selected most pathways UBR4 participated on our site, such as Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | ACTN2,GTF2A2,GTF2H3,SCIN,TRAF1,STAT3,HDAC1,H2-Q10,H2BFWT,ACTN3 |
Protein Function
UBR4 has several biochemical functions, for example, calmodulin binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR4 itself. We selected most functions UBR4 had, and list some proteins which have the same functions with UBR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | NOS3,SNTB2,MYO7A,PHKG1A,CALD1B,CNN1,PPP3CC,ADD2,DAPK1,KCNQ3 |
| zinc ion binding | AFG3L2,PRKCB,AGBL2,RNF152,MATR3L,ATRX,ADH6,TCEA2,RFPL2,MARCH11 |
| ubiquitin-protein transferase activity | TSPAN17,TRAF6,LTN1,XIAP,RBCK1,TRAF4B,TRAF2,HERC2,PEX12,RNF31 |
| protein binding | AGR2,NPHS1,CAML,SNRPN,AZI2,FNDC3B,ADA,HSPG2,ZNF131,PLA2G16 |
| ligase activity | PELI3,TTLL4,HUWE1,TRIM27,TRIM23,TRIM38,HECW1B,RNF152,TRIM41,BIRC7 |
Interacting Protein
UBR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR4.
E7;VCAM1;gag-pol;E7;E7;MCRS1;PRPF40A;SRGN;UBE2A;UBE2B;Smad6;Nsfl1c
Resources
Related Services
Related Products
References
- Parsons, K; Nakatani, Y; et al. p600/UBR4 in the central nervous system. CELLULAR AND MOLECULAR LIFE SCIENCES 72:1149-1160(2015).
- Aoyagi, N; Watanabe, M; et al. Optical properties of tetravalent uranium complexes in non-aqueous media. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 303:1095-1098(2015).
