UBQLN2
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Official Full Name
ubiquilin 2 -
Overview
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. -
Synonyms
UBQLN2;ubiquilin 2;ubiquilin-2;Chap1;CHAP1/DSK2;Dsk2;LIC 2;N4BP4;NEDD4 binding protein 4;PLIC 2;PLIC2;RIHFB2157;ubiquitin-like product Chap1/Dsk2;protein linking IAP with cytoskeleton 2;ALS15;HRIHFB2157
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UBQLN2-3559H | Recombinant Human UBQLN2, GST-tagged | E.coli | Human | GST | 1-624aa | |
| UBQLN2-613H | Recombinant Human UBQLN2 Protein, His-tagged | E.coli | Human | His | Ile33~Ala126 | |
| UBQLN2-17756M | Recombinant Mouse UBQLN2 Protein | Mammalian Cell | Mouse | His |
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| UBQLN2-46H | Recombinant Human UBQLN2 protein, His-tagged | E.coli | Human | His | 1-624 aa |
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| UBQLN2-96H | Recombinant Human UBQLN2, GST-tagged | Wheat Germ | Human | GST |
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| UBQLN2-545HF | Recombinant Full Length Human UBQLN2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 624 amino acids |
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| UBQLN2-5838H | Recombinant Human UBQLN2 Protein (Ile33-Ala126), N-GST tagged | E.coli | Human | GST | Ile33-Ala126 |
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| UBQLN2-9856M | Recombinant Mouse UBQLN2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| UBQLN2-9856M-B | Recombinant Mouse UBQLN2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
UBQLN2 involved in several pathways and played different roles in them. We selected most pathways UBQLN2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBQLN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | RAD23AB,MAN1A1,MAPK8B,LMAN1,PPP1R15A,UBE2D4,BCL2A,MAPK9,SEC61AL2,UBE2D2A |
Protein Function
UBQLN2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBQLN2 itself. We selected most functions UBQLN2 had, and list some proteins which have the same functions with UBQLN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIAH1,BCAR1,PURA,HHIP,UBE2W,SKA3,DNMT3B,FXYD7,UBL7,MRC2 |
Interacting Protein
UBQLN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBQLN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBQLN2.
ADRM1;RAD23A;RPN13;RPN10;RPN10;PSMD4;ATXN7;PRPF40A;C1QA;CD93
Resources
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References
- Ajroud-Driss, S; Siddique, T; et al. Sporadic and hereditary amyotrophic lateral sclerosis (ALS). BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:679-684(2015).
- Osaka, M; Ito, D; et al. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 24:1617-1629(2015).
