UBE2V1

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  • Overview
  • Review / Q&A

  • Official Full Name

    ubiquitin-conjugating enzyme E2 variant 1

  • Overview

    Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

  • Synonyms

    UBE2V1;ubiquitin-conjugating enzyme E2 variant 1;UBE2V;CROC 1;CROC1;UEV 1;UEV1A;DNA-binding protein;TRAF6-regulated IKK activator 1 beta Uev1A;CIR1;UEV1;UEV-1;CROC-1

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • GST
  • His
  • Non
  • Strep
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
UBE2V1-3548H Recombinant Human UBE2V1, GST-tagged E.coli Human GST 17-109aa
UBE2V1-109H Recombinant Human UBE2V1 protein, His-tagged E.coli Human His 162aa(including fusion tag)
UBE2V1-3527Z Recombinant Zebrafish UBE2V1 Mammalian Cells Zebrafish His
UBE2V1-4508C Recombinant Chicken UBE2V1 Mammalian Cells Chicken His
UBE2V1-5068R Recombinant Rhesus monkey UBE2V1 Protein, His-tagged Mammalian Cells Rhesus macaque His
UBE2V1-560HCL Recombinant Human UBE2V1 293 Cell Lysate HEK293 Human Non
UBE2V1-0519H Recombinant Human UBE2V1 Protein (A2-N147), Tag Free Insect Cells Human Non A2-N147
UBE2V1-0520H Recombinant Human UBE2V1 Protein (A2-N147), His/Strep tagged Insect Cells Human His&Strep A2-N147
UBE2V1-2298H Recombinant Human UBE2V1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
UBE2V1-2298H-B Recombinant Human UBE2V1 Protein Pre-coupled Magnetic Beads HEK293 Human
UBE2V1-4881R Recombinant Rhesus Macaque UBE2V1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
UBE2V1-4881R-B Recombinant Rhesus Macaque UBE2V1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Ube2v1-6800M Recombinant Mouse Ube2v1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
UBE2V1-819HFL Recombinant Full Length Human UBE2V1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

Involved Pathway

UBE2V1 involved in several pathways and played different roles in them. We selected most pathways UBE2V1 participated on our site, such as Activated TLR4 signalling,Adaptive Immune System,Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2V1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class I MHC mediated antigen processing &amp SEC61B,FCGR1B,PJA2,FBXO44,CTSL2,WSB1,UBE2U,DZIP3,SPSB2,UBE2F
Activated TLR4 signalling CHUK,TIRAP,S100A12,MAPK14,PELI1,DHX9,TICAM1,JUN,CREB1,APPA
CLEC7A (Dectin-1) signaling CASP8L1,MALT1,IL1B2,TAB1,AHCYL1
Cytokine Signaling in Immune system FRS2B,DUSP9,NUPL2,IRF9,TRIM2,TRIM26,GBP6,SPTB,HERC5,FGF10B
Downstream TCR signaling TRAT1,HLA-DQB2
Proteasome degradation KLHL20,UBE2L6,WSB1,HECTD3,NPEPPS,UFL1,MKRN1,RNF111,RNF19B,DTX3L
C-type lectin receptors (CLRs) TAB1,IL1B2,CLEC4D,CASP8L1,AHCYL1,CREBBP,ITPR2,MALT1,CLEC4A,CLEC6A
Antigen processing: Ubiquitination &amp UBR1,ARIH2,RNF111,TRIM11,SPSB2,FBXO27,SPSB4,HECTD3,KLHL20,ASB9
presentation ASB13,DTX3L,ASB14,RNF19B,ATG7,FBXO17,FBXO44,CD207,LRRC41,TRIM11

Protein Function

UBE2V1 has several biochemical functions, for example, protein binding,ubiquitin conjugating enzyme activity,ubiquitin conjugating enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2V1 itself. We selected most functions UBE2V1 had, and list some proteins which have the same functions with UBE2V1. You can find most of the proteins on our site.

Function Related Protein
ubiquitin protein ligase activity NHLRC1,RNF6,RNF115,RNF2,RNF149,PJA1,UBE2A,TRIM24,RBX1,WWP2
ubiquitin conjugating enzyme activity UBE2J2,UBE2Q2,UBE2E2,UBE2E1,UBE2D4,UBE2Z,UBE2G1,UBE2D3,UBE2A,UBE2Q1
ubiquitin protein ligase binding UBE2NB,SLC22A18,UCHL1,STX8,PRKAR2B,JKAMP,PRKAR1A,ERLIN2,RPA2,UBE2R2
ubiquitin conjugating enzyme binding FOXL2,RNF19B,DCUN1D3,RNF14,TOLLIP,RASD2,ARIH1L,RNF144AB,GRIK2,MARCH6
protein binding OAZ1,C16orf53,GPRC5A,AHSA1,DCX,BACH1,EBF2,COA5,ZC3H11A,VAMP3

Interacting Protein

UBE2V1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2V1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2V1.

UBE2N;XIAP

Resources

Research Area

Ubiquitin-related Molecules in the Akt Pathway
DNA Damage and Repair
E2 Ubiquitin/Ubl Conjugating Enzymes
Post-translational Modification of NFkB/IkB

References

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