UBE2V1
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Official Full Name
ubiquitin-conjugating enzyme E2 variant 1 -
Overview
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. -
Synonyms
UBE2V1;ubiquitin-conjugating enzyme E2 variant 1;UBE2V;CROC 1;CROC1;UEV 1;UEV1A;DNA-binding protein;TRAF6-regulated IKK activator 1 beta Uev1A;CIR1;UEV1;UEV-1;CROC-1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
UBE2V1 involved in several pathways and played different roles in them. We selected most pathways UBE2V1 participated on our site, such as Activated TLR4 signalling,Adaptive Immune System,Antigen processing: Ubiquitination &, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2V1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CLEC7A (Dectin-1) signaling | IL1B2,AHCYL1,TAB1,MALT1,CASP8L1 |
| Antigen processing: Ubiquitination & | CMTM2A,UBE2L6,BLMH,SPSB2,TRIM9,RNF138,ASB8,RNF41,UBE2J2,FBXO3 |
| Proteasome degradation | RNF25,RNF14,SPSB4,PJA1,LTN1,UBE2F,RNF182,RBCK1,TRIM69,LRRC41 |
| C-type lectin receptors (CLRs) | ITPR2,CLEC4A,MALT1,CREBBP,CASP8L1,IL1B2,TAB1,CLEC6A,AHCYL1,CLEC4D |
| Activated TLR4 signalling | RIPK3,IRAK3,CREB1B,TNIP2,TIRAP,DUSP7,DUSP6,DUSP4,PELI1,TAB1 |
| Cytokine Signaling in Immune system | IFI30,KPNA3,TRIM31,FCGR1B,UBE2L6,IL1RN,MX2,PELI1,EDARADD,FGF10B |
| Adaptive Immune System | DCTN1,CD200,WWP1,HUWE1,IFI30,TPP2,AP1S1,ERAP2,DYNC1H1,NRG4 |
| Class I MHC mediated antigen processing & | RNF34,CYBA,ASB10,UBE2U,ASB3,HUWE1,ASB18,ASB9,TRIM39,SPSB1 |
| presentation | FCGR1B,UFL1,RNF14,DTX3L,RNF4,NPEPPS,CYBB,PJA1,FBXO3,RNF182 |
Protein Function
UBE2V1 has several biochemical functions, for example, protein binding,ubiquitin conjugating enzyme activity,ubiquitin conjugating enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2V1 itself. We selected most functions UBE2V1 had, and list some proteins which have the same functions with UBE2V1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RNF6,SIAH1,CMTM2A,HLTF,MED20,FBXO30,UHRF2,HECTD3,RBBP6,RNF19A |
| ubiquitin conjugating enzyme activity | UBE2D1,UBE2Q1,UBE2J1,UBE2C,UBE2H,UBE2D3,UBE2J2,UBE2D2,UBE2QL1,UBE2A |
| ubiquitin conjugating enzyme binding | ARIH1L,RNF19A,ARIH2,GRIK2,DCUN1D5,PPARA,ANKIB1A,DCUN1D2A,TOLLIP,DCUN1D3 |
| protein binding | AGGF1,SF3B2,BRCA1,PLAUR,KRT4,NR1H4,VIPR1,KISS1,CIB3,CD200 |
| ubiquitin protein ligase binding | ARRB1,ZFP746,UBE2A,HSPA8,CCDC50,CUL3B,PTPN22,WASH1,AURKA,PRKACB |
Interacting Protein
UBE2V1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2V1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2V1.
UBE2N;XIAP
Resources
Research Area
Ubiquitin-related Molecules in the Akt PathwayDNA Damage and Repair
E2 Ubiquitin/Ubl Conjugating Enzymes
Post-translational Modification of NFkB/IkB
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