UBE2H
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Official Full Name
ubiquitin-conjugating enzyme E2H -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. -
Synonyms
UBE2H;ubiquitin-conjugating enzyme E2H;ubiquitin conjugating enzyme E2H (homologous to yeast UBC8) , ubiquitin conjugating enzyme E2H (UBC8 homolog, yeast);ubiquitin-conjugating enzyme E2 H;UBC8;UBCH;E2 20K;Ubc H2;UBCH 2;UBCH2;UBE2H_HUMAN;Ubiquitin carrier protein H;Ubiquitin conjugating enzyme E2 H;Ubiquitin conjugating enzyme E2H (UBC8 homolog yeast);Ubiquitin conjugating enzyme E2H;Ubiquitin protein ligase H;Ubiquitin-conjugating enzyme E2-20K;Ubiquitin-protein ligase H;OTTHUMP00000212335;OTTHUMP00000212338;OTTHUMP00000212339;OTTHUMP00000212355;ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast);E2-20K
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- E. coli
- HIS
- His
- His&SUMO
- Non
- His&Strep
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
UBE2H involved in several pathways and played different roles in them. We selected most pathways UBE2H participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE2E3,UBE2E1,SMURF1,CUL3,NEDD4,UBE3B,UBE2I,ANAPC4,UBE2E2,CUL5 |
Protein Function
UBE2H has several biochemical functions, for example, ATP binding,protein binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2H itself. We selected most functions UBE2H had, and list some proteins which have the same functions with UBE2H. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | SIAH1A,ZNRF3,UBE2R2,TRAF3,BIRC3,PARK2,TRAF5,MARCH5,UBE2D2,RNF151 |
| ATP binding | DCLK1A,ATP2C2,DDX53,ACVR1L,AACS,HELB,ADK,PANK1A,PI4K2B,APAF1 |
| ubiquitin conjugating enzyme activity | UBE2R2,CDC34,UBE2E3,UBE2QL1,UBE2V2,UBE2D2,UBE2G1,UBE2S,UBE2G2,UBE2Q2 |
| ubiquitin protein ligase activity | SIAH2,CCNC,NHLRC1,UBE2G1A,MED1,RNF222,FBXO30,UBE2C,UBE2T,MSL2A |
| ubiquitin protein ligase binding | JKAMP,ACTG1,CASP8,RNF31,UBE2C,SPOP,MC1R,GABARAPL1,BAG5,MID1 |
| protein binding | CUL4A,ACTN3,LILRB3,LILRA4,MAP3K7IP3,SHISA5,RBM25,PER2,Icosl,NUDT10 |
Interacting Protein
UBE2H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2H here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2H.
MAGEC2;MAGEA2;NHLRC1;RNF103;DNM1L;NEURL1;UBOX5;TRIM37;TRIM27;TRIM23;DHPS;RNF144A;RNF4;MKRN3;ZBTB17;LRSAM1;BRAP
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References
- Quadri, M; Yang, X; et al. An exome study of Parkinson's disease in Sardinia, a Mediterranean genetic isolate. NEUROGENETICS 16:55-64(2015).
- Nguyen, N; Yi, JS; et al. Mitsugumin 53 (MG53) Ligase Ubiquitinates Focal Adhesion Kinase during Skeletal Myogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:3209-3216(2014).
