UBE2G2
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Official Full Name
ubiquitin-conjugating enzyme E2G 2 -
Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
UBE2G2;ubiquitin-conjugating enzyme E2G 2;ubiquitin conjugating enzyme E2G 2 (homologous to yeast UBC7) , ubiquitin conjugating enzyme E2G 2 (UBC7 homolog, yeast);ubiquitin-conjugating enzyme E2 G2;UBC7;ubiquitin-protein ligase G2;ubiquitin carrier
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- E. coli
- HEK293T
- His
- Non
- His&SUMO
- GST
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UBE2G2 involved in several pathways and played different roles in them. We selected most pathways UBE2G2 participated on our site, such as Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2G2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | FLJ11011L,BRCA1,UBE3A,DET1,ANAPC5,ANAPC7,UBE2O,CUL2,UBE2D2L,TRAF6 |
| Protein processing in endoplasmic reticulum | EIF2AK3,AMFR,EDEM3,UBE2J1,SEC23B,UBE2D2L,UBE4B,DNAJC5,HSP26,UBE2D3 |
| Parkinsons disease | SLC25A31,GNAI2,MT-ND4,NDUFB4,NDUFA12,UQCRB,COX6A2,NDUFS4,UBE2J1,COX7A2 |
Protein Function
UBE2G2 has several biochemical functions, for example, ATP binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2G2 itself. We selected most functions UBE2G2 had, and list some proteins which have the same functions with UBE2G2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | GLMN,EGR2,MAGEA2,SUMO2,CUL4A,WASH,TRAF4,PER3,TRIM28,ABI2 |
| ATP binding | MYO15,TOR2A,SARS,UCKL1A,SLFNL1,AK4,MAPK1,SGK3,PDIK1L,DNAH6 |
| ubiquitin conjugating enzyme activity | UBE2D1,CDC34,UBE2H,UBE2G1,UBE2V1,UBE2Z,UBE2D3,UBE2O,UBE2D2A,UBE2D4 |
| protein binding | ARHGEF40,BIRC2,NAP1L1,PEAK1,SESTD1,ASPSCR1,ERN1,DDX47,CTCF,ZFAND2B |
| identical protein binding | TNK2,SHANK1,C14orf166,CRYAA,DRD4,MRI1,PRKD1,SERPINA1E,CBX3,TYSND1 |
| ubiquitin protein ligase activity | RNF6,RNF2,LTN1,UBE2G1B,HERC4,ZSWIM2,PDZRN4,CDC42,ARIH1L,TRIM6 |
| ubiquitin-protein transferase activity | RNF125,UBE2D1,NEDD4L,FBXO3,RNF217,FBXO7,UBR4,PEX12,TRIM62,TSPAN17 |
Interacting Protein
UBE2G2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2G2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2G2.
AMFR;CORO1A
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References
- Ambivero, CT; Cilenti, L; et al. Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP. CELLULAR SIGNALLING 26:2921-2929(2014).
- Liu, WX; Shang, YL; et al. gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains. SCIENTIFIC REPORTS 4:-(2014).
