UBC1
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Official Full Name
ubiquitin-conjugating enzyme E2 1 -
Overview
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING;finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntingtons disease. Known functions for;this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis;in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the;endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different;isoforms have been identified for this gene. -
Synonyms
UBC1;ubiquitin-conjugating enzyme E2 1;AT1G14400;ATUBC1;F14L17.17;F14L17_17;UBIQUITIN CARRIER PROTEIN 1;UBIQUITIN CONJUGATING ENZYME 1;Ubiquitin protein ligase;ubiquitin carrier protein 1 (UBC1);CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608);BEST Arabidopsis thaliana protein match is: ubiquiting-conjugating enzyme 2 (TAIR:AT2G02760.1);Has 10640 Blast hits to 10586 proteins in 402 species: Archae - 0;Bacteria - 2;Metazoa - 4553;Fungi - 2331;Plants - 2017;Viruses - 26;Other Eukaryotes - 1711 (source: NCBI BLink).
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Involved Pathway
UBC1 involved in several pathways and played different roles in them. We selected most pathways UBC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UBC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
UBC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by UBC1 itself. We selected most functions UBC1 had, and list some proteins which have the same functions with UBC1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
UBC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBC1.
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