Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway SMAD4,PPARDB,SOX17,PRICKLE1,FZD8B,MYCB,NLK2,PRKCBB,RAC1B,FOSL1
    Pathways in cancer SUFU,NFKB2,BMP4,KRAS,PLEKHG5,PIK3CB,FGF17,FZD5,AXIN2,CCND1
    Bladder cancer TP53,DAPK2,MAPK1,CDK4,EGF,E2F2,E2F1,HBEGF,NRAS,MAP2K1
    Hepatitis C MAPK11,IFN-a,NFKB1,CXCL8,PPP2CB,STAT1,IFNA16,EIF2AK3,OAS2,GRB2
    Epstein-Barr virus infection TRAF6,TNFAIP3,SYK,CD40,TRAF5,XPO1,TRADD,HSPA1A,IL10RB,POLR2J
    Glioma PDGFB,PLCG1,MAPK1,PIK3R5,AKT2,IGF1R,CALML3,CALM2,SOS1,CCND1
    Melanoma FGF5,FGF3,MITF,MAP2K1,FGF10,HGF,KRAS,FGF8,NRAS,RB1
    Amyotrophic lateral sclerosis (ALS) CCS,PPP3R1,APAF1,MAP3K5,CAT,DAXX,CASP12,TNFRSF1B,SLC1A2,PPP3R2
    Central carbon metabolism in cancer NTRK1,NRAS,PKM2,RAF1,PIK3R2,FGFR2,HK3,PGAM1,SLC16A3,PFKM

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding MED25,PDX1,TAF1,SMARCD3,GTF2A2,HDAC3,SMARCA4,KCNA3,SMAD3,SIRT1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MAFK,DLX2,FOXO3,ETV5,GLIS1,ESRRG,GATA4,FOXC1,MAFBB,FEZF2
    ubiquitin protein ligase binding NLK,UCHL1,RELA,PIAS1,GABARAPL2,FAF2,ACVR1B,TRAF1,SPG20,CUL1
    p53 binding MDM2,SIRT1,NUAK1,ZFP385C,ZNF346,PLK3,ANKRD1,RNF34,TP53BP1,SETD8
    RNA polymerase II core promoter sequence-specific DNA binding SFPI1,TFAP2A,NLRC5,PAX6,GATA6,NFIL3,STAT6,SMAD1,RREB1,SMYD3
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FEV,FLI1B,SP1,ZNF174,TFAP2A,ETV2,TFAP2E,FOXB1,FOXQ2,PAX6A
    protein heterodimerization activity APOA2,TPD52,USF1,HIST3H2A,BAXB,RXRA,HER1,H3F3C,BRAF,BAD
    receptor tyrosine kinase binding ARHGEF16,ANXA5,ZNF259,TP53,PTPN14,HYAL2,SHC4,SHC3,ANGPT4,SOCS5
    metal ion binding ZC3H8,MBNL1,KSR2,ASXL3,ZMYM2,CYP2P7,CECR1A,ZC4H2,KLF16,ZNF548

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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