Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK&Myc
  • Avi&Fc&His

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Huntingtons disease DNAIC2,DNAI1,ATP5A1,NDUFAB1,NDUFC2,POLR2G,POLR2E,PLCB2,NDUFA9,SDHC
    Herpes simplex infection SP100,C5,IFNB,OAS1A,SRSF3,TAF5L,HLA-DQA1,EIF2AK2,PPP1CA,TAF10
    Bladder cancer E2F1,DAPK3,TYMP,EGF,UPK3A,MAPK1,KRAS,E2F2,ARAF,MMP1
    Measles BBC3,CD209,NFKBIB,MAVS,TRAF6,TLR9,HSPA6,CD3G,SH2D1A,PIK3R5
    HTLV-I infection PPP3R2,GM-CSF,SLC2A1,FOS,VAC14,IL2RB,AKT2,HLA-DMA,BAX,PIK3R3
    Endometrial cancer PIK3CG,PIK3CA,BRAF,PIK3CD,PIK3R2,APC2,TCF7L2,PIK3R3,APC,PIK3CB
    MicroRNAs in cancer NOTCH3,MDM4,IKBKB,GLS,RPS6KA5,SOX4,MMP9,ABCB1,PRKCA,PLCG2
    Hepatitis B PIK3CD,TLR3,MAP2K2,IFNA21,OSTN,CASP12,CYCS,RB1,Ifna11,IFNA8
    Colorectal cancer APC,GSK3B,CCND1,RAF1,SMAD2,AKT1,TGFB2,PIK3CA,PIK3R3,TGFB3

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding AAAS,TP53RK,RCHY1,PSME3,CREBBP,TRIM29,EP300,PLK3,CDKN2A,TP53
    protein heterodimerization activity NKX2-5,HYPM,ITGB1,TBX15,PPARD,PDGFA,HIST1H3H,MAFGA,MEF2C,CREB3L3
    ubiquitin protein ligase binding SQSTM1,PCBP2,CHEK2,PRKAR2B,UCHL1,CD40,PTPN22,SMAD2,NLK,TOLLIP
    ATP binding GSS,DAPK2A,AK4,PRKX,KITB,EPHA4B,DDX18,STK35,EPHB4,EPHB3A
    sequence-specific DNA binding DMRT2A,IKZF4,CENPB,POUV,DMRT3A,MAFG,ZBTB49,LBX1,FOXB1A,IRX3
    RNA polymerase II core promoter sequence-specific DNA binding MITF,NFIL3,SFPI1,NR4A2,GATA1,MAZ,YAP1,TCF7L2,H3F3B,HNF4A
    protein phosphatase binding ROS1,CDH5,EGFR,Itga10&Itgb1,PPARG,AP3B1,ANAPC5,MAP3K5,GNB2L1,TRAF3
    protease binding INS,Cstb,FURIN,NFRKB,TTN,XBP1,RYR1,FADD,TIMP2B,SERPINA1
    double-stranded DNA binding RBMS1,LSM14A,MTERFD3,AFF3,XRCC3,KLF6,TP63,XRCC2,TEF,MCM10

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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