Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prostate Cancer GRB2,PIK3CA,IKBKG,NKX3-1,PIK3CG,PDGFRA,RAF1,SMARCC2,MAP4K1,PIK3R1
    Chronic myeloid leukemia CCND1,MAPK3,CTBP2,HDAC1,PIK3R3,PIK3CB,STAT5A,CBLC,RAF1,PIK3R1
    Central carbon metabolism in cancer MET,PTEN,MAP2K1,HK2,FGFR3,FGFR1,MAPK3,AKT1,LDHA,PKM2
    Pancreatic cancer STAT1,SMAD2,RAD51,TGFBR1,PIK3CB,CDC42,KRAS,PIK3CG,SMAD4,MAPK8
    Neurotrophin signaling pathway MAPK7,NTF4,RPS6KA2,RAF1,SORT1,ZFP110,NRAS,MAPK9,CALM4,BAD
    MicroRNAs in cancer PLAU,CCND1,BMPR2,CDCA5,HDAC4,TTC6,RECK,FZD3,MAPK1,DNMT3A
    MAPK signaling pathway PLA2G4C,CASP3A,FGF10,CACNG4,PPP3CB,RASGRF2B,ZAK,MAP3K3,MAPK9,PAK2B
    Non-small cell lung cancer AKT1,RARB,NRAS,STK4,RB1,FHIT,FOXO3,HRAS,CCND1,RXRG
    Transcriptional misregulation in cancer MLLT3,ERG,ELANE,LMO2,LYL1,TSPAN7,HIST1H3G,Aff1,GZMB,RXRB

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding GATA3,CREBBP,PRDM13,ZKSCAN3,ATXN7,BRD2,ORC1L,KAT2B,TPR,NOC3L
    protein self-association NKX3-1,SYP,CCL5,RYR2,PABPN1,AGTR1B,TTN,ZKSCAN17,SLC9A3R1,RSAD2
    histone deacetylase regulator activity MAPK8,NCOR1,TP53
    core promoter sequence-specific DNA binding MTA1,NFYA,REST,ESR1,NRIP1,NRF1,ATF4,KLF10,ZFP750,CHD2
    MDM2/MDM4 family protein binding PSME3,CDK5RAP3,PPARA,CDKN2A,RFWD3,CAV1
    transcription cofactor binding KLF4,FOXO3,CHD6
    copper ion binding MT1,HIST2H3A,S100U,SOD1,DCT,SCO1,LOXL1,DBH,PRND,AOC2
    RNA polymerase II transcription factor binding ZGLP1,GSK3B,GSC,MIXL1,T,CREBBP,TP53,TAL1,KDM1A,NFATC1
    metal ion binding SCD5,DICER1,HBB-B2,MTBL,GMIP,HMOX2,GDPD2,ZNF263,PCXA,GNS

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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