TUFM
-
Official Full Name
Tu translation elongation factor, mitochondrial -
Overview
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. -
Synonyms
TUFM;Tu translation elongation factor, mitochondrial;elongation factor Tu, mitochondrial;EF TuMT;EFTu;COXPD4;EF Tu;EFTuMT;P43;EF-Tu;OTTHUMP00000122539;EF-TuMT
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- Yeast
- HEK293
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
TUFM involved in several pathways and played different roles in them. We selected most pathways TUFM participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUFM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | MRPL51,EXOC8,MKKS,RP2,AURKAIP1,TCTN3,CEP97,POLG2,IFT80,MRPS22 |
| Mitochondrial translation | DAP3,MRPL51,MRPL50,MRPS35,MRPL41,MRPL28,MRPL54,MRRF,MRPS22,MRPS23 |
| Mitochondrial translation elongation | MRPL41,DAP3,TSFM,MRPS25,MRPL10,MRPL52,MRPS23,MRPS34,MRPL55,MRPS26 |
Protein Function
TUFM has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TUFM itself. We selected most functions TUFM had, and list some proteins which have the same functions with TUFM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | HMGB1,AGO2,KCTD12,MTHFSD,DIDO1,NAP1L4,ACAA2,C14orf166,USO1,DMGDH |
| translation elongation factor activity | EEF2A.1,EEF2A.2,TSFM,EIF5A,EEF1B2,EEF1A2,EEF1DB,EEF1A1L1,EEF1D,EEF1G |
| GTPase activity | TUBA8,NKIRAS1,GNG3,RAB3DB,RAB8B,RAB24,RALBA,RABL2,RAB20,ARHGDIB |
| protein binding | FBXO28,CHP,PDCL,ZNF202,MAPK8,KIF3A,GDAP2,SLC11A2,CTNNBIP1,GP1BA |
| GTP binding | GNL1,RHOUB,RND3A,GUCY1A3,RHOC,RASL11A,EEF1A1B,GTPBP2,RAB9A,EHD4 |
Interacting Protein
TUFM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUFM here. Most of them are supplied by our site. Hope this information will be useful for your research of TUFM.
ARL6IP1;FUNDC1;FAM9B;CMTM5;PPP2R2B;7242199;SGK1;CFLAR;EPB41;TNFRSF1B;MCC
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